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Immune Reconstitution Syndrome (IRS/IRIS)

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Despite ART, Immune System Ages Faster Among People Living With HIV, Study Finds

Even with an undetectable viral load, study participants who had been vaccinated as children lost smallpox immunity.

By Sony Salzman
PET scans show areas of high FDG (glucose) uptake in an individual before (pink outline) and after (blue outline) receiving antiretroviral therapy for HIV infection. In the second image, the spike in sugar-hungry cells corresponds to a diagnosis of immune

Video SNiP: PET Scan 'Hot Spots' Help Visualize Inflammatory Complication of HIV

Researchers are working to visualize and predict immune reconstitution syndrome (IRIS) in people with HIV in a new way -- with positron emission tomography (PET).

By National Institute of Allergy and Infectious Diseases
Five-Drug Early HIV Treatment Does Not Correct Inflammation or Immune Deficits Img

Five-Drug Early HIV Treatment Does Not Correct Inflammation or Immune Deficits

Starting five-drug antiretroviral therapy (ART) very early did not quell HIV-associated inflammation in a randomized comparison with standard ART.

By Mark Mascolini
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Lymph Node Fibrosis, CD4 T Cells, and Immune Reconstitution

One of the less well-publicized consequences of the persistent immune activation caused by HIV infection is a type of scarring damage to lymph tissues described as fibrosis. Some early studies of lymph nodes from HIV-infected individuals reported evi...

By Richard Jefferys for Treatment Action Group
Ongoing HIV Infection Could Explain Low CD4 Counts Despite Undetectable Viral Loads, Study Suggests Img

Ongoing HIV Infection Could Explain Low CD4 Counts Despite Undetectable Viral Loads, Study Suggests

Even if people start HIV treatment late, they still have a good chance at recovery. However, not everyone benefits equally: For instance, some people seem to have poor CD4 count gains even when HIV meds are working well. New research explores why....

By Warren Tong
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The Price of Progress: A Review of Immune Reconstitution Syndrome

Background

William Powderly, from University College in Dublin, Ireland, presented an excellent review of the current state of knowledge regarding the relatively uncommon condition called immune reconstitution syndrome (IRS), which is a syndrome kno...

By Margaret Hoffman-Terry, M.D., F.A.C.P.
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Immune Reconstitution Syndrome

Syndrome Identified Conditions Associated With Inflammatory Reactions Mechanism of Action Incidence Risk Factors Management Grounds for Optimism Selected Sources

Immune reconstitution, or the reversal of HIV-related immune system dec...

By Nicholas Cheonis for San Francisco AIDS Foundation
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CD4 Cell Recovery and Thymic Volume

Thymic Volume Is Independently Associated With the Magnitude of CD4+ T-Cell Recovery After Short and Long Term on HAART (Oral 16) Authored by E. Ruiz-Mateos, A. Vallejo, A. Rubio, N. Soriano, R. de la Rosa, S. Molina, A. Sánchez-Quijano, E. Lis...

By Mark Holodniy, M.D.
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Immune Response to HIV May Damage Lymph Nodes, Lower CD4 Counts in Some

University of Minnesota researchers may have unlocked another key mystery surrounding HIV. Their discovery appears to explain why a quarter of HIV patients respond poorly to drug cocktails while others show dramatic improvements.

Dr. Timothy Schacke...

By CDC National Prevention Information Network
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Earlier Initiation of HAART Better Preserves Functional Immune Competence Even in Persons Who Achieve "Normal" CD4+ T-Cell Counts

Earlier Initiation of HAART Better Preserves Functional Immune Competence Even in Persons Who Achieve "Normal" CD4+ T-Cell Counts (LbOr09) Authored by C. Lange, H. Valdez, K. Medvik, R. Asaad, M. Wild, R. Kalayjian, M. LedermanView the original...

By Judith A. Aberg, M.D., F.I.D.S.A.