Influenza vaccine response is lower in people living with HIV (PLWH) than in those not living with the virus, and that difference is even more pronounced among people under the age of 40, a study published in AIDS found.
Researchers tested flu antibodies in 315 participants, 151 of whom were PLWH with undetectable viral loads, before and after influenza vaccination. Among most participants, antibody titers were already in the seroprotective range before vaccination -- likely due to previous bouts of flu and/or influenza vaccinations, researchers speculated. Antibodies -- especially to the H1N1 and B influenza strains -- increased for everyone after the vaccine was administered. However, more participants in the HIV arm did not respond to the vaccine than in the non-HIV arm. When stratified by age (under 40, 60 or older, or 40-59 years old), antibodies against the B strain were lower in PLWH compared to similarly-aged people who do not live with HIV.
"High-potency influenza vaccination recommended for healthy aging could be considered for HIV+ adults of all ages," study authors concluded.