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FDA Approves Doravirine (Pifeltro) and New FDC With TDF/3TC (Delstrigo) in the U.S.

On Aug. 30, 2018, the U.S. FDA approved doravirine as a separate formulation for use with ART and in a fixed-dose combination with generic tenofovir DF and lamivudine (3TC).

By Simon Collins for HIV i-Base

More People With HIV Virally Suppressed on Doravirine Than Darunavir at 96 Weeks, Study Shows

After 96 weeks, more people achieved viral suppression on a doravirine-based antiretroviral drug regimen compared with a darunavir (Prezista)-based one, according to data presented at the recent 22nd International AIDS Conference.

By Barbara Jungwirth

ARVs and Children: New Research Shows the Devastating Impact of a Late Start

The first global comparison of adolescents who acquired HIV as newborns highlights the challenges around treatment for children in developing countries.

By Mary-Ann Davies and Amy Slogrove for The Conversation

Symtuza: FDA Approves New Fixed-Dose Combination for Treatment of HIV

On July 17, 2018 the U.S. Food and Drug Administration approved Symtuza, a four-drug combination indicated as a complete regimen for the treatment of HIV-1 infection in adults.

By U.S. Food and Drug Administration

Study Shows Depressive Symptoms Associated With Detectable HIV Viral Load, but Not With Missed Visits

Adherence to HIV care visits was associated more with mental health conditions before starting antiretroviral treatment than with recent depressive symptoms, while a detectable viral load was related to such symptoms.

By Barbara Jungwirth

Latest DHHS Guidelines for Initial HIV Therapy Now Include 5 Choices -- but Really 2 Are Best

On March 28, the Department of Health and Human Services Guidelines issued an update to the HIV treatment guidelines, with a focus on the recent approval of bictegravir/TAF/FTC.

By Paul E. Sax, M.D. for NEJM Journal Watch

Heavy Marijuana Use Linked to Heart Problems in HIV-Positive People

Researchers found that heavy marijuana use increased the risk for complications of cardiovascular disease -- including heart attack and stroke -- regardless of whether the study participants also smoked tobacco and regardless of the presence of other...

By Sean R. Hosein for Canadian AIDS Treatment Information Exchange

Will De-Simplification of HIV Treatment Become Common in High-Income Countries?

As more people start HIV treatment, researchers are exploring ways to cut costs. Single tablets can be replaced by a few pills comprising cheaper generic drugs.

By Sean R. Hosein for Canadian AIDS Treatment Information Exchange

Who Tends to Gain Weight With HIV Treatment?

Researchers found that people taking common combinations of HIV drugs had increases in weight and body mass index, and those who were relatively thin or older prior to starting therapy were most likely to gain weight.

By Sean R. Hosein for Canadian AIDS Treatment Information Exchange

Study Links Gut-Homing Protein Levels With HIV Infection Risk, Disease Progression

For the first time, scientists have shown a relationship between the proportion of key immune cells that display high levels of a gut-homing protein called alpha-4 beta-7 at the time of HIV infection and health outcomes.

By National Institute of Allergy and Infectious Diseases