Stavudine (d4T, Zerit)

The Latest

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Ending Global Use of d4T: UNITAID to Tip Market to Safer Alternatives

On 11 June 2013, UNITAID announced in a press statement that it was committing USD $77 million to end of the use of the archaic HIV drug d4T (stavudine) and replace it with tenofovir which is a newer more effective alternative.1

Although d4T was wid...

By Simon Collins for HIV i-Base
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d4T -- Time to Move On

The first conference of the Southern African Clinician's Society1 burst into life with a demonstration by the Treatment Action Campaign (TAC).

TAC were unequivocal that repurposing d4T at any dose is not an acceptable way to conquer cost concerns wi...

By Polly Clayden for HIV i-Base
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Children (Ages 0-17)

High Prevalence of d4T-Associated Lipodystrophy Including Lipoatrophy in Children

Data describing lipodystrophy in children from sub-Saharan Africa are extremely limited. However use of d4T is widespread among children receiving ART in the region: in 2008 to 2009 approximately 90% of children on ART were taking d4T.

Two posters a...

By Polly Clayden for HIV i-Base
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New Labeling for Zerit Capsules and Zerit for Oral Solution

On December 10, 2010, the FDA approved new labeling for Zerit capsules and Zerit for oral solution. The revisions to the Dosage and Administration, Warnings and Precautions, Adverse Reaction sections in both package inserts are outlined below.


By U.S. Food and Drug Administration
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Hepatitis C

Both Tenofovir and Stavudine Well Tolerated in HCV-Coinfected Patients

The Gilead 903 study was an open-label, randomized clinical trial that compared tenofovir (TDF, Viread) with stavudine (d4T, Zerit). All of the patients in that study also received lamivudine (3TC, Epivir) and efavirenz (EFV, Sustiva, Stocrin). As ha...

By Paul E. Sax, M.D.
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Lipodystrophy/Body Fat

Predicting Lipoatrophy After Treatment Initiation

I liked this study. Mustafa Noor and the Bristol-Myers Squibb (BMS) group did a post-hoc analysis of a recent, large, randomized trial that compared the use of the currently available formulation of stavudine (d4T, Zerit) and stavudine extended relea...

By Pablo Tebas, M.D.
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A Comparison of AZT/3TC vs. d4T/ddI, Plus Efavirenz, Nevirapine or Indinavir/Ritonavir

Controversy still exists regarding which is the best antiretroviral therapy (ART) to start with. We all agree that the regimen must be potent, safe, well tolerated, convenient for the individual, and must demonstrate both efficacy and durability.


By Judith A. Aberg, M.D., F.I.D.S.A.
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South Africa

South African Generic Drug Maker to Produce Country's First Generic Antiretroviral Drug

Aspen Pharmacare, southern Africa's largest generic drug manufacturer, yesterday announced that it will develop and produce the continent's first generic antiretroviral drug, called Aspen-Stavudine, South Africa's Mail & Guardian reports (Mail & Guar...

By Henry J. Kaiser Family Foundation
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More Results Reported on Study 903: Tenofovir + 3TC + Efavirenz Vs. d4T + 3TC + Efavirenz

Characterization of Virologic Failure Through 96 Weeks Among Treatment-Naive Patients Taking Tenofovir DF (TDF) or Stavudine (d4T) in Combination With Lamivudine (3TC) and Efavirenz (EFV) (Poster 553) Authored by M.D. Miller, N.A. Margot, D.J. ...

By Calvin Cohen, M.D., M.S.
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Trizivir Causes Lowest Triglycerides Rise in Comparison With Combivir + Nelfinavir or d4T

Prospective Study of Hyperlipidemia in ART-Naive Subjects Taking Trizivir (TZV), Combivir (COM)/Nelfinavir (NFV), or Stavudine (d4T)/Lamivudine (3TC)/NFV (Poster 709) Authored by P. Kumar, A. Rodriguez-French, M. Thompson, K. Tashima, P. Wannam...

By Timothy Wilkin, M.D., M.P.H.