This will likely become the landmark study about the overall rate of neuropsychiatric side effects with this class of medicines over the next several years.
Integrase inhibitors are associated with greater increases in body weight than other antiretrovirals, especially among women and black people. But it's unclear whether these changes are clinically significant.
The impact of stigma on cognitive performance; risk factor dissonance among young black MSM; pregnancy and the HIV care continuum; new data on pediatric raltegravir use.
Chewable raltegravir tablets can be crushed and stirred until dispersed in water, apple juice or breast milk and given to younger children according to WHO weight bands.
In late June 2017, Health Canada licensed the sale and use of a new formulation of the anti-HIV drug raltegravir (Isentress) as part of the treatment of HIV.
Daily raltegravir was safe and well tolerated at six weeks of life and met pharmacokinetic targets in HIV-exposed infants, according to data presented at CROI 2017.
Five case studies from Uganda showed good responses in children and adolescents receiving raltegravir-based third-line ART.
A large U.S. ACTG study reported significantly different body changes with raltegravir compared to combinations using a boosted PI.