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HIV Treatment Strategies

HIV Treatments in Development

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The Role of Vaccines and Cures in HIV Elimination Img

The Role of Vaccines and Cures in HIV Elimination

Even a moderately efficacious HIV vaccine could make a significant additional contribution to halting the virus. And for HIV-positive people, a true end to HIV lies not in an epidemiological calculus, but in a cure.

Novel Drugs in the Pipeline for HIV Treatment Img
Features

Novel Drugs in the Pipeline for HIV Treatment

The antiretrovial therapy pipeline includes new medications in existing drug classes as well as medications with novel mechanisms of action.

Elite Controllers: Sex Differences and Factors Associated With Loss of Immune Control Img

Elite Controllers: Sex Differences and Factors Associated With Loss of Immune Control

The ability of elite controllers to maintain undetectable viral loads and relatively preserved CD4 T-cell counts in the absence of antiretroviral therapy has led them to be proposed as a model for a functional cure of HIV infection.

Inching Towards an HIV Cure: bNAb and TLR-7 Agonist Reduce Viral Rebound Off-ART in Macaques Img
CROI (Conference on Retroviruses and Opportunistic Infections)

Inching Towards an HIV Cure: bNAb and TLR-7 Agonist Reduce Viral Rebound Off-ART in Macaques

Results from a proof-of-principle study in macaques showing that treatment with broadly neutralising antibodies might play a role in key stages for an HIV cure.

No HIV Evolution in Plasma or Lymph Nodes on Suppressive ART and No Impact From Further Intensification Img
CROI (Conference on Retroviruses and Opportunistic Infections)

No HIV Evolution in Plasma or Lymph Nodes on Suppressive ART and No Impact From Further Intensification

Two studies presented at CROI 2018 support the idea that ART reaches everywhere in the body that it needs to, and that residual ongoing HIV replication comes from HIV infected cells that were archived before ART was started.

Assessing Antiretroviral Therapy Interruptions in HIV Cure Research Img

Assessing Antiretroviral Therapy Interruptions in HIV Cure Research

During a clinical trial of the broadly neutralizing antibody VRC01, study results offered reassurance that treatment interruption had no long-term negative effects for participants -- but there are some possible safety concerns that the data does not...

Slight Changes to Broadly Neutralizing HIV Antibody Yield Great Dividends Img

Slight Changes to Broadly Neutralizing HIV Antibody Yield Great Dividends

Researchers have demonstrated that a slight change to a powerful, naturally occurring HIV antibody helps it last longer in the human body while counteracting the virus just as well in the laboratory.

HIV Cure: Squaring What's Medically Possible With Public Expectations Img

HIV Cure: Squaring What's Medically Possible With Public Expectations

A large survey conducted among people living with HIV in the U.S. asked the question: "What does a 'cure for HIV' mean to you?"

Recruiting Natural Killer Cells to Target HIV Persistence Img

Recruiting Natural Killer Cells to Target HIV Persistence

There is growing interest in cells considered part of the innate immune system, particularly natural killer (NK) cells. A number of studies have been published that support the idea that NK cells can play an important role in controlling virus replic...

New Data on Identifying and Targeting the Latent HIV Reservoir Img

New Data on Identifying and Targeting the Latent HIV Reservoir

Several recently presented and published studies offer potentially important new data relevant to efforts to identify cells containing latent HIV and target them for elimination.