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HIV Treatments in Development

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The Only Cases of HIV Cure or Remission

Over the past few years, a tiny – but slowly growing – number of people appeared to have had active, living, reproducing HIV completely eliminated from their bodies.

UK Patient Likely to Be the Second Person Cured of HIV: Two Further Cases at CROI 2019 of HIV Remission After Allogenic Stem Cell Transplants Img
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UK Patient Likely to Be the Second Person Cured of HIV: Two Further Cases at CROI 2019 of HIV Remission After Allogenic Stem Cell Transplants

The procedure used in this case was similar to that used in the only previously confirmed HIV cure case, "Berlin patient" Timothy Ray Brown, albeit with a somewhat less aggressive approach.

Are Integrase Inhibitors Linked to Weight Gain? An Evidence Review Img

Are Integrase Inhibitors Linked to Weight Gain? An Evidence Review

Integrase inhibitors are associated with greater increases in body weight than other antiretrovirals, especially among women and black people. But it's unclear whether these changes are clinically significant.

The Long-Acting Bandwagon: A Top HIV Clinical Development of 2018 Img

The Long-Acting Bandwagon: A Top HIV Clinical Development of 2018

Word is getting out that, barring some major setback, long-acting injectable HIV antiretrovirals will soon be coming our way. Patients have come to my clinic asking about it; others muse that they wish there were shots instead of pills, and are heart...

Designing HIV-Resistant People: A Top HIV Clinical Development of 2018 Img

Designing HIV-Resistant People: A Top HIV Clinical Development of 2018

As unsavory as probably it is to most of us, there's big news in the claim by He Jiankui, Ph.D., that he was able to use Crispr-Cas9 technology to alter the genes of twin girls so they were born with their CD4 cells not expressing the CCR5 co-recepto...

Monkey Study Uncovers the Potential for Vesatolimod and Antibodies in HIV Cure Research Img

Monkey Study Uncovers the Potential for Vesatolimod and Antibodies in HIV Cure Research

Researchers hope that by interacting with the toll-like receptor protein TLR-7 an experimental drug can help increase the immune system's ability to sense and attack HIV and HIV-infected cells.

Keeping an Eye on Intellectual Property Issues in HIV Cure and Prevention Research Img

Keeping an Eye on Intellectual Property Issues in HIV Cure and Prevention Research

"As exemplified by the AZT protests, advocates have long pointed out the injustice of excessive, access-limiting profiteering on treatments developed with public support."

Combinations of Super Antibodies May Keep HIV at Bay Img

Combinations of Super Antibodies May Keep HIV at Bay

The results from this pilot study are exciting and raise many issues that need to be taken into account for future studies of broadly neutralizing antibodies.

As a Strategy for HIV Prevention, Disabling the CCR5 Gene in Embryos Implanted in HIV-Negative Mothers Makes Zero Sense Img

As a Strategy for HIV Prevention, Disabling the CCR5 Gene in Embryos Implanted in HIV-Negative Mothers Makes Zero Sense

Paul Sax, M.D., puts it bluntly: "[I]t makes zero sense to do this since the babies aren't at risk of getting HIV to begin with."

World's First Gene-Edited Babies? Premature, Dangerous and Irresponsible Img

World's First Gene-Edited Babies? Premature, Dangerous and Irresponsible

A Chinese scientist claims to have edited human DNA to make us more resistant to HIV. Here's why that's not good news.