"We believe this is one of the first immune-based therapies to show a very profound reduction in inflammatory markers in the setting of treated HIV," Priscilla Hsue, M.D. states.
Two cohort studies showed a higher risk of IRIS with integrase inhibitor-based ART than with other regimens.
Scientists at The Scripps Research Institute (TSRI) have discovered a way of creating HIV- resistant cells by using antibodies to block HIV directly on the cell surface.
Combined with tenofovir alafenamide/emtricitabine (TAF/FTC, Descovy), the investigational HIV integrase inhibitor bictegravir matched the licensed integrase inhibitor dolutegravir (Tivicay, DTG) in viral suppression and safety, according to phase-2 s...
Bictegravir-containing regimens performed well over 48 weeks, with more than 90% of participants achieving a viral load less than 50 copies/mL.
The experimental integrase inhibitor being developed by Gilead Sciences is currently in phase III clinical trials.
The new nucleoside analogue GS-9131 may be useful as part of regimens for people who have strains of drug-resistant HIV.
A recent clinical trial found that doravirine was roughly equivalent in potency to darunavir-based regimens.
At the recent Conference on Retroviruses and Opportunistic Infections, researchers presented data about 5 new anti-HIV compounds in development.
In a small cross-sectional study researchers found a link between the use of integrase inhibitors and the presence of low testosterone, but they may have inadvertently arrived at this conclusion.