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HIV Treatment Strategies

HIV Treatments in Development

The Latest

Bictegravir -- An Emerging Integrase Inhibitor Img
CROI (Conference on Retroviruses and Opportunistic Infections)

Bictegravir -- An Emerging Integrase Inhibitor

Bictegravir-containing regimens performed well over 48 weeks, with more than 90% of participants achieving a viral load less than 50 copies/mL.

A New Nuke in the Works -- GS-9131 Img
CROI (Conference on Retroviruses and Opportunistic Infections)

A New Nuke in the Works -- GS-9131

The new nucleoside analogue GS-9131 may be useful as part of regimens for people who have strains of drug-resistant HIV.

Doravirine versus Darunavir Img
CROI (Conference on Retroviruses and Opportunistic Infections)

Doravirine versus Darunavir

A recent clinical trial found that doravirine was roughly equivalent in potency to darunavir-based regimens.

New Drugs, New Hope and Possible Timelines Img
CROI (Conference on Retroviruses and Opportunistic Infections)

New Drugs, New Hope and Possible Timelines

At the recent Conference on Retroviruses and Opportunistic Infections, researchers presented data about 5 new anti-HIV compounds in development.

The Capsid Inhibitor -- A New Class to Enter Clinical Trials Img
CROI (Conference on Retroviruses and Opportunistic Infections)

The Capsid Inhibitor -- A New Class to Enter Clinical Trials

A capsid inhibitor could affect three parts of HIV's life cycle and could be used by itself in the prevention of HIV infection. However, much work lies ahead before this drug's developer can be certain about that.

Do Integrase Inhibitors Affect Testosterone Levels in Men? Img
Endocrine/Sexual Dysfunction

Do Integrase Inhibitors Affect Testosterone Levels in Men?

In a small cross-sectional study researchers found a link between the use of integrase inhibitors and the presence of low testosterone, but they may have inadvertently arrived at this conclusion.

Increased Risk of IRIS With Integrase Inhibitors Reported in Two Studies Img
CROI (Conference on Retroviruses and Opportunistic Infections)

Increased Risk of IRIS With Integrase Inhibitors Reported in Two Studies

Two cohort studies presented at CROI 2017 showed a higher risk of IRIS with integrase inhibitor-based ART than with other regimens.

Flagging the HIV Reservoir: A Potential New Marker for CD4 Cells Hiding HIV Img

Flagging the HIV Reservoir: A Potential New Marker for CD4 Cells Hiding HIV

New research shows that it may be possible to identify many latently infected CD4 T cells due to expression of a particular cell surface protein.

Long-Acting Cabotegravir Injection Protects Macaques From SIV Img

Long-Acting Cabotegravir Injection Protects Macaques From SIV

One injection of long-acting cabotegravir (CAB LA) protected 21 of 24 macaques from intravenous challenge with simian immunodeficiency virus (SIV).

Monkeys Suppress HIV-Like Virus for Extended Period After Dual-Antibody Treatment Img

Monkeys Suppress HIV-Like Virus for Extended Period After Dual-Antibody Treatment

Giving monkeys two powerful anti-HIV antibodies immediately after infection with an HIV-like virus enabled the immune systems of some of the animals to control the virus long after the antibodies were gone.