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HIV Basic Science and Pathogenesis

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News

This Week in HIV Research: Getting Smart(Phone) About HIV Detection

A cellphone attachment that detects HIV RNA; HIV-2 does indeed often progress to AIDS; CD4 count declines and incident hepatitis C coinfection; the global demographics of non-Hodgkin lymphoma.

PET scans show areas of high FDG (glucose) uptake in an individual before (pink outline) and after (blue outline) receiving antiretroviral therapy for HIV infection. In the second image, the spike in sugar-hungry cells corresponds to a diagnosis of immune
Immune Reconstitution Syndrome (IRS/IRIS)

Video SNiP: PET Scan 'Hot Spots' Help Visualize Inflammatory Complication of HIV

Researchers are working to visualize and predict immune reconstitution syndrome (IRIS) in people with HIV in a new way -- with positron emission tomography (PET).

Colorized scanning electron micrograph of a B cell from a human donor

During HIV Infection, Antibody Can Block B Cells From Fighting Pathogens

For the first time, scientists have shown that in certain people living with HIV, a type of antibody called immunoglobulin G3 (IgG3) stops the immune system's B cells from doing their normal job of fighting pathogens.

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Hepatitis C

This Week in HIV Research: Heavier Health Burdens Begin Before Diagnosis

Prevalence of non-AIDS comorbidities prior to HIV diagnosis; wealth and HIV treatment access amidst universal health care; the uncertain benefits of food supplementation; the results of universal hepatitis C treatment access.

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Cardiovascular

This Week in HIV Research: How Discrimination Feeds Cigarette Use

Tobacco use and HIV discrimination; enhancing viral suppression after prison with naltrexone; asymptomatic myocardial impairment during acute HIV infection; undetectability and yellow fever vaccine efficacy.

Canakinumab in HIV Reduces Inflammation Img

Canakinumab in HIV Reduces Inflammation

Researchers tested a single injection of the antibody canakinumab in HIV-positive people taking antiretroviral therapy and found that the drug significantly reduced inflammation and did not cause harm, at least in the short term.

Inflammation in Arteries vs. Lymph Nodes Img

Inflammation in Arteries vs. Lymph Nodes

Researchers found that inflammation in the arteries of HIV-positive people was "modestly increased" and that the level of inflammation in the lymph nodes was generally higher than in the arteries.

suPAR -- An Early Warning Signal for Chronic Inflammation Img

suPAR -- An Early Warning Signal for Chronic Inflammation

Researchers have found that having an elevated level of a protein that is released into the blood of people during chronic inflammation was linked to an increased risk for subsequent serious health problems as well as diminished survival.

Exploring HIV and Inflammation Img

Exploring HIV and Inflammation

Chronic HIV infection is associated with relatively high levels of inflammation and a growing body of evidence suggests that inflammation may increase the risk for a range of health problems.

Inflammation-Related Illness Among HIV-Positive People Img

Inflammation-Related Illness Among HIV-Positive People

New research assesses the impact of chronic inflammation on major clinical events -- heart attack, stroke, cancer, other serious complications, and the risk of death.