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HIV Basic Science and Pathogenesis

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Study Links Alcohol Intake to HIV Progression

HIV-infected patients who are drinkers tend to have higher levels of the virus in their blood and lower CD4 counts than similar patients who do not drink, according to a preliminary study. However, this was seen only in patients taking antiretroviral...

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HIV-1 Env-Chemokine Receptor Interactions in Primary Human Macrophages: Entry and Beyond

Abstract

While HIV has subverted the chemokine receptors CCR5 and CXCR4 for its own use as an entry co-receptor, their normal functions are to transduce signals in response to extracellular ligands. Our lab is interested in understanding how HIV-1 g...

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Interferon-Producing Plasmacytoid Dendritic Cells and the Pathogenesis of AIDS

Abstract

Interferon-alpha (IFN-a) generation by peripheral blood mononuclear cells (PBMC) responding in vitro to HSV was first found to be deficient in patients with severe ulcerative herpes simplex virus (HSV) infections early in the AIDS epidemic....

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HIV Captured on Film in Earliest Stages

University of Illinois-Chicago researchers have captured for the first time the very earliest stages of HIV infection in living cells. Using protein dyes from jellyfish and time-elapsed microscopy, they saw color images of individual HIV particles tr...

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Gene Pattern Helps Postpone AIDS Progression

People who have a particular genetic pattern are less likely than others to progress quickly to AIDS when infected with HIV, according to research published in Monday's online edition of Nature Genetics. The genetic pattern includes a gene that codes...

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AIDS Treatment News Denialist Series

In our last issue we completed our series of articles, mostly by Bruce Mirken, answering the "AIDS denialist" assertions that HIV is harmless (or does not exist), HIV treatment should be avoided, HIV-related medical tests are inaccurate and useless, ...

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HIV-Specific Cellular Immune Responses in Patients With Immunologic Control of Viral Replication

HIV-Specific Cellular Immune Responses in Patients with Immunologic Control of Viral Replication Abstract 1083 Presented by Mark Connors (NIH/NIAID/LIR, Bethesda, MD) View the original abstract

A critical area of research focus in HIV ...

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The Immune System: Behind the Scenes

Curtain Up Immunity's Stage Immunity's Script Cytokines and Chemokines Immunity's Actors Granulocytes Mononuclear Phagocytes Dendritic Cells Natural Killer Cells Complement T-Cells B-Cells and A...

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High HIV Levels Shut Down Anti-HIV Immune Responses

New research suggests that HIV-specific T cells persist in infected individuals, but high virus levels can diminish the ability of those cells to respond to infection. The report sheds new light on how HIV evades the immune system and establishes lo...

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Restoring Immunity in HIV Disease

Introduction Challenges with Highly Active Antiretroviral Therapy (HAART) Immune Deficiency in HIV Infection Potential for Restoration of HIV-Specific Immunity with HAART Prospects for Immune Reconstitution with IL-2 Therapy Conclusions

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