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HIV Basic Science and Pathogenesis

CROI (Conference on Retroviruses and Opportunistic Infections)

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Viral Reservoir Can Explain Persistent Low Level Viremia With Good Adherence on ART Img

Viral Reservoir Can Explain Persistent Low Level Viremia With Good Adherence on ART

A CROI 2019 study suggests the dynamics of HIV proliferation in the viral reservoir might explain why viral load sometimes fails to become undetectable, especially when adherence is good.

Dolutegravir More Effective Than Efavirenz at Achieving Viral Suppression During Late-Term Pregnancy, New Study Shows Img

Dolutegravir More Effective Than Efavirenz at Achieving Viral Suppression During Late-Term Pregnancy, New Study Shows

Unlike some previous studies that focused on early pregnancy, this study showed no associated congenital disabilities with either drug.

What You Need to Know About the Second Person Likely Cured of HIV Img

What You Need to Know About the Second Person Likely Cured of HIV

Richard Jefferys, an expert in HIV cure research, spoke to TheBodyPro about this new case of HIV remission -- and the danger in rushing to publish these stories, especially for people who live with stigma.

UK Patient Likely to Be the Second Person Cured of HIV: Two Further Cases at CROI 2019 of HIV Remission After Allogenic Stem Cell Transplants Img

UK Patient Likely to Be the Second Person Cured of HIV: Two Further Cases at CROI 2019 of HIV Remission After Allogenic Stem Cell Transplants

The procedure used in this case was similar to that used in the only previously confirmed HIV cure case, "Berlin patient" Timothy Ray Brown, albeit with a somewhat less aggressive approach.

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CROI 2019: What News to Expect in HIV Science and Policy

TheBodyPro is covering all the latest in HIV science at the biggest annual gathering of HIV researchers in the U.S. Here's a preview of what's to come.

Markers of Immune Exhaustion Predict Post-Treatment Control in HIV Patients Img

Markers of Immune Exhaustion Predict Post-Treatment Control in HIV Patients

Biomarkers of immune exhaustion were associated with how long a patient was able to control HIV after treatment was interrupted, according to a study presented at CROI 2015.

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Catching Up With Pathogenesis and Cure Research From CROI 2014

In addition to studies covered in prior posts (a possible second pediatric cure case, Sangamo's gene therapy and limitations of latency-reversing agents), CROI 2014 featured a smorgasbord of presentations related to pathogenesis and cure research. We...

"Immune" to HIV? Not So Fast Img

"Immune" to HIV? Not So Fast

A particular type of mutation renders people with HIV effectively immune to most strains of the virus. (The "Berlin patient," Timothy Brown, was essentially "given" this type of mutation.) But as a new case report shows, these individuals are still v...

Impact of Monocytes on Inflammation and Aging in HIV Img

Impact of Monocytes on Inflammation and Aging in HIV

This study compared a small group of HIV-infected women with matched HIV-uninfected controls and found that HIV-infected women had similar levels of immune activation of monocytes compared to HIV-uninfected women 16 years older.

Monocytes are critic...