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First-Line HIV Treatment

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HIV Antiretroviral Therapy: Past, Present and Future

In the last two decades, antiretroviral therapy has dramatically improved the health of people living with HIV. Let’s take a brief look at the past and present before we look forward to HIV treatment in 2020.

Jens Lundgren on When to Start HIV Treatment (Video) Img

Jens Lundgren on When to Start HIV Treatment (Video)

The START study, co-chaired by Jens Lundgren, M.D., director of the Centre for Viral Diseases at Copenhagen University, convincingly showed the benefits of beginning antiretroviral treatment immediately after testing positive for HIV. Lundgren thinks...

The Day the HIV Treatment Pendulum Stopped Swinging Img

The Day the HIV Treatment Pendulum Stopped Swinging

People expected the START study results to be good. But they never expected them to be this good.

HIV Remission for More Than 12 Years After Very Early Treatment in French Teenager Img

HIV Remission for More Than 12 Years After Very Early Treatment in French Teenager

An 18-year-old female has been able to maintain an undetectable viral load for more than 12 years after interrupting early antiretroviral treatment, according to a study presented at IAS 2015.

HIV Treatment at High CD4 Counts Protects Against Both AIDS and Non-AIDS Events in the START Study: Overall and in Subgroup Analyses Img

HIV Treatment at High CD4 Counts Protects Against Both AIDS and Non-AIDS Events in the START Study: Overall and in Subgroup Analyses

Earlier this year, we learned that the START study had found overwhelming evidence that beginning HIV antiretroviral therapy at any CD4 count was better than waiting. At IAS 2015, we got our first detailed look at the data.

A Tenofovir-Sparing Regimen Could Be a Safer Alternative for Starting Treatment Img

A Tenofovir-Sparing Regimen Could Be a Safer Alternative for Starting Treatment

The ACTG A5303 study at CROI 2015 was a double-blind, randomized trial that compared maraviroc (Selzentry, Celsentri), at 150 mg once daily, to tenofovir (TDF, Viread) in 259 treatment-naive patients, both arms with ritonavir (Norvir)-boosted darunav...

Fat Gains After Starting HIV Treatment Associated With High Viral Loads Img

Fat Gains After Starting HIV Treatment Associated With High Viral Loads

Having a high viral load when starting treatment was most consistently associated with body composition changes after starting antiretroviral therapy.

HIV Transmission Risk Remains During First 6 Months of Treatment Img

HIV Transmission Risk Remains During First 6 Months of Treatment

A person living with HIV can transmit the virus during the first six months of starting treatment. Researchers suggest extra prevention strategies for mixed-status couples during this period before viral suppression is achieved.

Starting HIV Treatment Early Leads to Better Health and Improved Immune Systems Img

Starting HIV Treatment Early Leads to Better Health and Improved Immune Systems

Two studies presented at CROI 2015 provided results that describe the benefits to starting HIV treatment early, in terms of time (within three months of infection) and in terms of CD4 count (greater than 350 cells).

Abdominal Body Fat Gains on ART and Viral Load: It Matters Where You Start Img

Abdominal Body Fat Gains on ART and Viral Load: It Matters Where You Start

Researchers found that people with higher viral loads when they first start ART are more likely to have substantial body composition changes than those who start treatment with a lower viral load.