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FDA-Approved HIV Medications

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HIV and Telaprevir Drug Interactions

Phase III clinical trials tend to enroll carefully selected patients who have few or mild-to-moderate pre-existing health conditions. In practice, once a drug is licensed, a wide variety of patients, some of whom may have multiple health conditions, ...

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Hepatitis C

HIV and Boceprevir Drug Interactions

Phase III clinical trials tend to enroll carefully selected patients who have few or mild-to-moderate pre-existing health conditions. In practice, once a drug is licensed, a wide variety of patients, some of whom may have multiple health conditions, ...

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Intranasal and Topical Corticosteroids and Risk of Cushing's Symptoms in HIV Patients on Ritonavir-Based Combinations

Although iatrogenic Cushing's syndrome has previously been reported as a complication from the drug-drug interaction between ritonavir and corticosteroids (we included two cases in HTB last year), two posters at BHIVA this year highlighted low awaren...

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African-Americans

Warfarin and ARVs: Impact of African-American Race and Ritonavir

The commonly prescribed anticoagulant warfarin is highly susceptible to interactions with antiretroviral mediated through CYP 2C9, 2C19, and/or 3A4 pathways, although data are limited.

This retrospective, case‐control (1:2) study compared the warfar...

What You Don't Know, You Can Sell Img
Hepatitis C

What You Don't Know, You Can Sell

Many people with HIV also have hepatitis C. So why did it take so long to see information about potentially serious interactions between HIV drugs and Victrelis (boceprevir), a new hep C medication? Activist Tracy Swan offers this sharp critique.

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Hepatitis C

Merck Says Hepatitis Pill Hampers HIV Drugs

Merck & Co.'s hepatitis C virus (HCV) treatment Victrelis (boceprevir) considerably lessens the effectiveness of some widely used HIV drugs, U.S. regulators and Merck recently announced.

"These drug interactions may be clinically significant for pat...

Boceprevir/PI Interaction: A "Dear Doctor" Letter We Didn't Want to Get Img
Hepatitis C

Boceprevir/PI Interaction: A "Dear Doctor" Letter We Didn't Want to Get

By now I'm sure that most of you ID folks out there have received the following letter from Merck, the makers of boceprevir:

URGENT — IMPORTANT DRUG WARNING: VICTRELIS (BOCEPREVIR)

The purpose of this communication is to inform you of recent p...

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Bristol-Myers, Gilead Work on New Combo HIV Pill

Bristol-Myers Squibb Co. and Gilead Sciences Inc. announced Wednesday a deal to develop and sell a once-a-day HIV pill that combines a popular protease inhibitor (PI) with a boosting agent.

Under the plan, Bristol-Myers will formulate, manufacture, ...

ICAAC HIV Poster Roundup #1: Clinically Relevant Findings Img
News

ICAAC HIV Poster Roundup #1: Clinically Relevant Findings

Here's a quick sampling of some of the more noteworthy HIV-related posters presented at a major research conference last week. Topics covered include a surprisingly high frequency of people quitting Atripla due to side effects; the decline of multidr...

Study: HIV Risks Rise With Some Birth Control Img

Study: HIV Risks Rise With Some Birth Control

Hormone-based contraception may be associated with an increased risk both of HIV acquisition (by HIV-negative women) and HIV transmission (from HIV-positive women to men) during sex, according to a recent study. However, the findings still need to be...