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Conference Coverage

Making Right Turns in the HIV Pharmacology Maze: 5th International Workshop on Clinical Pharmacology of HIV Therapy

Introduction How Much Does the Host Matter? Pharmacology News on New Antiretrovirals Drug-Drug Interactions -- Good, Bad, or Neither References


All roads lead to Rome, they say. But once you get there, none of them leads anyw...

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New HIV Protease Inhibitors: New Options in the PI Class for Treatment-Naive Persons

Introduction Benefits of Early Protease Inhibitors Limitations of Early Protease Inhibitors Challenges to Protease Inhibitors: Non-Nucleoside RT Inhibitors The Rise of Boosted PIs Therapeutic Challenges and New Protease Inhibitors New P...

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Case Study: Drug-Drug Interactions Associated With the Use of Antiretroviral Therapy


A 30 year-old male inmate with class B3 HIV/AIDS and a history of injection drug use, idiopathic thrombocytopenic purpura (ITP), upper gastrointestinal bleeding, and chronic untreated hepatitis C presents to you for an initial evaluation one we...

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Dual-PI Regimen Preferred Over Single-PI Regimen After Initial PI Failure

The selection of a second treatment regimen after an initial treatment failure is becoming easier as our armamentarium of antiretroviral agents expands. Currently, for patients failing an initial NNRTI-based regimen, the decision for a second regimen...

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Gilead Aims to Begin Evaluation of New Protease Inhibitor

Gilead Sciences Inc. has submitted an investigational new-drug application to the Food and Drug Administration to evaluate GS 9005, a potential protease inhibitor therapy that could be taken once daily. The drug's creator said GS 9005 might have a re...

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HIV 101: Drug Interactions With HAART and Methadone

DrugEffect of Antiretroviral Therapy on MethadoneEffect of Methadone on Antiretroviral TherapyNucleoside/Nucleotide AnaloguesAbacavirDecreased methadone clearance 25%Decreased abacavir peak concentration 34%Didanosine, buffered tabletUnknownDecreased...

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Clinically Significant Drug Interactions Associated With Highly Active Antiretroviral Therapy

Introduction Drug Interaction Overview Nucleoside/Nucleotide Reverse Transcriptase Inhibitors Non-Nucleoside Reverse Transcriptase Inhibitors Protease Inhibitors Conclusions References


One of the most challenging issues f...

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Out of the Lab: A New Target and a New Agent From Gilead

This space reviews early laboratory findings from the Journal of Virology that shows scientists at work uncovering new ways to think about -- and ultimately beat the virus.

Betting on Betulinic Acid

In the January issue of the Journal of Virology, ...

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Pharmacokinetic Interactions of 908

All the pieces are falling into place before the expected FDA approval of GW433908, better known as "908," later this year. There were several presentations at this ICAAC clarifying several issues regarding the pharmacokinetic (PK) parameters and int...

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High Dose of Vitamin C Significantly Reduces Indinavir Levels in Pilot Study


Disturbingly few studies to date have focused on the potential impact of vitamins, minerals, herbal medicines and other supplements on the blood plasma levels of HIV antiretrovirals, particularly protease inhibitors. There are any number ...