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FDA-Approved HIV Medications

The Latest

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Psychiatric and HIV Medication Interactions

CategoryNNRTIsNRTIsPIsSSRIsProzac increases levels of Rescriptor 50%NPDProzac may lead to increased effects of Norvir, but no dose adjustment of Norvir is needed when used in combination. Norvir increases levels of Prozac, Luvox, Paxil, and Zoloft.TC...

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Atazanavir, With or Without Ritonavir, Should Not Be Coadministered With Proton Pump Inhibitors

Bristol-Myers Squibb has issued a Dear Healthcare Provider letter regarding important new pharmacokinetic data concerning the coadministration of Reyataz (atazanavir) and Norvir (ritonavir) with Prilosec (omeprazole). Omeprazole is a proton-pump inhi...

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How HIV Drugs Work

There are currently five categories of HIV antiviral drugs available that have FDA (U.S. Food and Drug Administration) approval. These categories are:

nucleoside reverse transcriptase inhibitors (NRTIs)

nucleotide reverse transcriptase inhibitors (...

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Cardiovascular

Warning Against Using Erythromycin (Even Orally) While Using Protease Inhibitors or Certain Other Drugs

An article in the September 9, 2004 New England Journal of Medicine reported that patients using the antibiotic erythromycin at the same time as drugs that strongly inhibited cytochrome P-450 3A (CYP3A, an enzyme in the liver that helps remove many d...

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Drug Interactions Fact Sheet

Introduction Drug List Glossary of Terms Anti-HIV Medications + Street Drugs: Some Cocktails Don't Mix

Introduction

With the number of drugs available to treat HIV and with those that prevent or treat opportunistic infections (OIs), the pot...

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Drug Monitoring and Pharmacology: More Mixes Nixed By Concentration Preoccupations

Statin StrengthRelative Potency of the HMG-CoA Reductase Inhibitors (a.k.a. Statins)DrugDaily DoseRelative PotencyFluvastatin (Lescol)60 mg1Pravastatin (Pravachol)60 mg2Lovastatin (Mevacor)20 mg3Simvastatin (Zocor)10 mg6Atorvastat...

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Cardiovascular

Protease Inhibitors Appear More Likely to Cause Atherosclerosis Than NNRTIs

Most protease inhibitors (PIs) have been associated with abnormal lipid profiles and insulin resistance, whereas better lipid profiles (such as an increase in high-density lipoprotein [HDL]) are seen with non-nucleoside reverse transcriptase inhibi...

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Confort Study Supports Switch From Protease Inhibitor to Nevirapine

Background

It is clear now that all but the most recently approved protease inhibitors (PIs) cause more gastrointestinal side effects and adverse effects on lipid profiles during treatment than the non-nucleoside reverse transcriptase inhibitors (NN...

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Tipranavir Reduces Concentrations of Other Protease Inhibitors

All protease inhibitors (PIs) are substrates, as well as inducers or inhibitors, of the CYP3A4 system. Combining PIs can either increase or decrease the concentration of each drug. While ritonavir (RTV, Norvir), a potent CYP3A4 inhibitor, is widely u...

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Tenofovir and Abacavir Do Not Interact in Patients on Triple-Nucleoside Regimens

Last year's 2nd IAS Conference in Paris will be remembered in part for the series of presentations showing the early failure of regimens containing the triple-nucleoside combination of lamivudine (3TC, Epivir), abacavir (ABC, Ziagen) and tenofovir (T...