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FDA-Approved HIV Medications

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News

Pharmacokinetic Data Show That Fosamprenavir + Atazanavir Combination Should Not Be Used

For HIV-infected patients with protease inhibitor (PI) resistance, there has been a lot of good news of late with the advent of PIs such as tipranavir (TPV, Aptivus) and TMC114. There also remains continued interest in the use of dual PIs for the tre...

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Quadruple-NRTI Regimen No More Desirable Than Triple-NRTI Regimen in Treatment-Naive Patients, Study Finds

Adding tenofovir (TDF, Viread) to zidovudine/lamivudine/abacavir (AZT/3TC/ABC, Trizivir) does not appear to improve virologic outcome and does nothing to reduce treatment discontinuation rates in treatment-naive patients, according to a relatively sm...

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Two NRTIs or Three? Makes No Difference When Taken With Efavirenz, ACTG 5095 Finds

When prescribing the potent antiretroviral efavirenz (EFV, Sustiva, Stocrin) as part of a first-line treatment regimen, there is no discernible difference between completing the regimen with two nucleoside reverse transcriptase inhibitors (NRTIs) or ...

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New Protease Inhibitor Brecanavir Shown to Be Safe and Effective in Small Study

A key dilemma for both patients and doctors is when to use new drugs and new drug classes. A thorough understanding of the characteristics of new drugs helps in choosing what to use and what potential combinations would be appropriate, or when to wai...

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Lipodystrophy/Body Fat

Protease Inhibitors Not Associated With Fat Gain; Some Antiretrovirals Can Cause Fat Loss, Study Says

Although some antiretroviral drugs are associated with weight loss in the extremities in HIV-positive men, weight gain is not associated with taking protease inhibitors, according to a study published in the Oct. 1 issue of the Journal of Acquired Im...

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Drug Interactions and Anti-HIV Therapy

Introduction A Ubiquitous and Growing Problem Mechanisms of Drug Interactions Pharmacodynamic Effects An Introduction to Pharmacokinetics Factors That Impact Drug Interactions Interactions Involving Antiretrovirals Interactions With O...

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Notice of Important New Drug Interactions With Norvir, Kaletra

The Norvir (ritonavir) and Kaletra (lopinavir/ritonavir) package inserts (product labeling) were recently updated to include information regarding interactions with fluticasone (a synthetic corticosteroid, the active component of Flonase nasal Spray)...

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Safety and Pharmacokinetic Data for 640385, a New Protease Inhibitor in Development

In July 2003, during the 2nd International AIDS Society Conference on Pathogenesis and Treatment, which was held in Paris, France,1 data were presented about the in vitro anti-HIV activity of a new protease inhibitor (PI) called 640385 (also known as...

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Tuberculosis

Drug Interaction Warning: Saquinavir/Ritonavir and Rifampin (Rifampicin, Rifadin, Rimactane, Rofact)

Roche Laboratories Inc. has issued a "Dear Health Care Provider" letter (PDF) to communicate an important drug interaction warning for saquinavir/ritonavir, used as part of combination therapy for treatment of HIV infection:

Drug-induced hepatitis w...

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Anti-HIV Drug Identification Chart: United States

Generic NameBrand NameAbbreviationPharmaceutical Co.Nucleoside Analog Reverse Transcriptase Inhibitors (NRTIs) & Nucleotide Analog Reverse Transcriptase Inhibitors (NtRTIs)abacavirZiagenABVGlaxoSmithKlinedidanosineVidexddIBristol-Myers Squibbdida...