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Adverse Events, Comorbidities, and HIV

Immune Reconstitution Syndrome (IRS/IRIS)

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PET scans show areas of high FDG (glucose) uptake in an individual before (pink outline) and after (blue outline) receiving antiretroviral therapy for HIV infection. In the second image, the spike in sugar-hungry cells corresponds to a diagnosis of immune

Video SNiP: PET Scan 'Hot Spots' Help Visualize Inflammatory Complication of HIV

Researchers are working to visualize and predict immune reconstitution syndrome (IRIS) in people with HIV in a new way -- with positron emission tomography (PET).

Five-Drug Early HIV Treatment Does Not Correct Inflammation or Immune Deficits Img

Five-Drug Early HIV Treatment Does Not Correct Inflammation or Immune Deficits

Starting five-drug antiretroviral therapy (ART) very early did not quell HIV-associated inflammation in a randomized comparison with standard ART.

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Lymph Node Fibrosis, CD4 T Cells, and Immune Reconstitution

One of the less well-publicized consequences of the persistent immune activation caused by HIV infection is a type of scarring damage to lymph tissues described as fibrosis. Some early studies of lymph nodes from HIV-infected individuals reported evi...

Ongoing HIV Infection Could Explain Low CD4 Counts Despite Undetectable Viral Loads, Study Suggests Img

Ongoing HIV Infection Could Explain Low CD4 Counts Despite Undetectable Viral Loads, Study Suggests

Even if people start HIV treatment late, they still have a good chance at recovery. However, not everyone benefits equally: For instance, some people seem to have poor CD4 count gains even when HIV meds are working well. New research explores why....

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The Price of Progress: A Review of Immune Reconstitution Syndrome

Background

William Powderly, from University College in Dublin, Ireland, presented an excellent review of the current state of knowledge regarding the relatively uncommon condition called immune reconstitution syndrome (IRS), which is a syndrome kno...

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Immune Reconstitution Syndrome

Syndrome Identified Conditions Associated With Inflammatory Reactions Mechanism of Action Incidence Risk Factors Management Grounds for Optimism Selected Sources

Immune reconstitution, or the reversal of HIV-related immune system dec...

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CD4 Cell Recovery and Thymic Volume

Thymic Volume Is Independently Associated With the Magnitude of CD4+ T-Cell Recovery After Short and Long Term on HAART (Oral 16) Authored by E. Ruiz-Mateos, A. Vallejo, A. Rubio, N. Soriano, R. de la Rosa, S. Molina, A. Sánchez-Quijano, E. Lis...

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Immune Response to HIV May Damage Lymph Nodes, Lower CD4 Counts in Some

University of Minnesota researchers may have unlocked another key mystery surrounding HIV. Their discovery appears to explain why a quarter of HIV patients respond poorly to drug cocktails while others show dramatic improvements.

Dr. Timothy Schacke...

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Earlier Initiation of HAART Better Preserves Functional Immune Competence Even in Persons Who Achieve "Normal" CD4+ T-Cell Counts

Earlier Initiation of HAART Better Preserves Functional Immune Competence Even in Persons Who Achieve "Normal" CD4+ T-Cell Counts (LbOr09) Authored by C. Lange, H. Valdez, K. Medvik, R. Asaad, M. Wild, R. Kalayjian, M. LedermanView the original...

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Immune Responses in Long-Term Non-Progressors -- Lessons for Immune Reconstitution

Immune Responses in Long-Term Non-Progressors -- Lessons for Immune Reconstitution (WeOrA199) Authored by Brigitte AutranNon-abstract driven session

Dr. Autran summarized past and new work performed by her group in Paris on the correlates of a...