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Abacavir (Ziagen)

Cardiovascular

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Abacavir, Platelets, and a Cardiovascular Verdict: A Top HIV Clinical Development of 2018 Img

Abacavir, Platelets, and a Cardiovascular Verdict: A Top HIV Clinical Development of 2018

Debates about the role of abacavir (Ziagen, ABC) in the development of cardiovascular disease in persons living with HIV have raged for over a decade, and a kind of stalemate has been achieved between those who are and are not convinced of a link. Wh...

Reducing Risk of Myocardial Infarction in HIV-Positive People Img

Reducing Risk of Myocardial Infarction in HIV-Positive People

This year at CROI 2018 a few studies tried to explore possible mechanisms for the association of increased myocardial infarction risk and abacavir use.

Abacavir Link to Cardiovascular Events in High-Risk Patients Maintained in D:A:D Study Img

Abacavir Link to Cardiovascular Events in High-Risk Patients Maintained in D:A:D Study

A poster at CROI 2014, presented by Caroline Sabin from University College London and colleagues, presented follow-up results from D:A:D since the initial findings in 2008 of a link between abacavir use and risk of myocardial infarction (MI) in peopl...

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FDA Report Suggests Abacavir May Not Increase Myocardial Infarction Risk After All

In a poster that was presented on March 2 at the 18th Conference on Retroviruses and Opportunistic Infections (CROI 2011), the U.S. Food and Drug Administration (FDA) reported that it has found no evidence of an association between abacavir (ABC, Zia...

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French Study Unexpectedly Uncovers Role of Substance Use in Heart Attacks

Several years ago researchers working with a large observational database called DAD (with more than 33,000 HIV-positive people) announced that they had found a link between the use of the anti-HIV drug abacavir (Ziagen and in Kivexa, Epzicom and Tri...

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Abacavir, Didanosine Associated With Higher Heart Attack Risk, D:A:D Study Finds

One of the most talked-about studies presented at CROI 2008 was authored by Caroline Sabin and colleagues on behalf of the large, international D:A:D cohort.1 It focused on the impact of specific antiretrovirals on heart attack risk in HIV-infected p...

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Increased Risk of Myocardial Infarction Associated With Abacavir and ddI

A poster presented by Caroline Sabin from the Royal Free Hospital looked at whether nucleoside analogues were associated with cardiovascular disease (CVD) seen in the large international D:A:D cohort study.1 D:A:D includes over 33,000 patients from 1...

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Simplification of Protease Inhibitor-Based Highly Active Antiretroviral Regimens With Abacavir Improves Hyperlipidemia and Maintains Viral Suppression in HIV-1-Infected Adults (ESS40003)

Simplification of Protease Inhibitor (PI)-Based Highly Active Antiretroviral Regimens With Abacavir (ABC) Improves Hyperlipidemia and Maintains Viral Suppression in HIV-1-Infected Adults (ESS40003) (WePeC6267) Authored by P. Keiser, M. Sension,...