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Latest by Treatment Action Group

Tuberculosis

Fool's Errand: The Sloppy Science of the MDR-TB STREAM Trial

They should have left well enough alone. The original design of a landmark clinical trial evaluating a shortened course of treatment for multidrug-resistant tuberculosis (MDR-TB) was just what was needed to confirm its potential benefits over the Wor...

The White House's Fuzzy Math Img

The White House's Fuzzy Math

On World AIDS Day, December 1, 2013, the White House Office of National AIDS Policy (ONAP) issued a peppy and upbeat status report on the National HIV/AIDS Strategy (NHAS), claiming progress on eight of nine outcome indicators. Yet when reviewed in t...

Forgotten Negatives: The Limits of Treatment as Prevention Img
Viewpoints

Forgotten Negatives: The Limits of Treatment as Prevention

There is no shortage of depressing statistics when it comes to HIV prevention in the United States: 50,000 new HIV infections annually; a 12% increase in new infections among gay and bisexual men and transgender women between 2008 and 2010; an estima...

Studies Highlight Shortcomings of Latency-Reversing Agents

The persistence of a latent form of HIV integrated into the genome of long-lived cells, particularly memory CD4 T cells, is considered the most significant barrier to curing the infection. A key element of cure research is the pursuit of strategies c...

Emerging Regulatory Issues in HIV Cure Research

Over the past several years, there has been a welcome invigoration of the research effort to cure HIV infection. The mainstream media has picked up on this development, and stories about putative or possible cures are appearing more frequently than i...

Circulating Memory T Follicular Helper Cells Correlate With the Development of Broadly Neutralizing Antibody Responses Against HIV

A study published on September 12th by the journal Immunity ties together two emerging areas of HIV vaccine research. In recent years, scientists have discovered that a small proportion of chronically infected individuals develop antibody responses c...

Lack of Efficacy and Safety Concerns Blight Adenovirus Vaccine Vectors

Vaccine vectors based on adenoviruses -- which are common in nature and cause severe colds -- were once viewed as promising for HIV and other intractable diseases due to their ability to induce antigen-specific CD8 T-cell responses in the majority of...

Sad News Regarding Attempt to Duplicate the Cure Achieved in Timothy Brown

In April, doctors at the University of Minnesota announced that they were attempting to reproduce the cure achieved in Timothy Brown in a 12-year old boy with HIV and leukemia who required a stem cell transplant. Due to the challenges associated with...

U.S. Centers for Disease Control and Prevention (CDC) Sponsored HIV Preexposure Prophylaxis (PrEP) Trial Among Thai Injection Drug Users Marred by Lack of Response to Community Concerns Img

U.S. Centers for Disease Control and Prevention (CDC) Sponsored HIV Preexposure Prophylaxis (PrEP) Trial Among Thai Injection Drug Users Marred by Lack of Response to Community Concerns

Despite its important findings, a major study "failed to promote basic ethical practices and patently ignored community concerns," according to an alliance of advocacy groups.

Searching for HIV in Timothy Brown, the Berlin Patient Img

Searching for HIV in Timothy Brown, the Berlin Patient

Why do we keep referring to Timothy Brown as "functionally" cured of HIV instead of just plain "cured"? A recently published study explores why it's so hard to truly prove a cure.