Latest by Richard Jefferys

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Vaccine Breakthrough Comes With Caveats

One of the main sources of pessimism about prospects for an effective HIV vaccine has been the generally poor results obtained in animal models. In particular, a stringent system involving rhesus macaque monkeys challenged with highly pathogenic simi...

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Microbicide Field Wrestles With the Implications of Success

In July of this year, the stubborn persistence and commitment of microbicide researchers, advocates, and trial participants was finally rewarded with positive results from a South African trial of the gel form of the antretroviral drug tenofovir (tra...

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Bananas Over BanLec

A study just published in the Journal of Biochemistry has generated a great deal of press coverage because it reports that a compound derived from bananas can inhibit HIV in a lab dish. The substance, a banana lectin known as BanLec, was first discov...

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NIAID Workshop: Elimination of HIV Reservoirs

On Friday, January 15, the National Institutes of Allergy & Infectious Diseases (NIAID) sponsored a scientific workshop entitled "The Next Challenge: Elimination of HIV Reservoirs." The event took place during the Keystone conference on HIV pathogene...

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Merck HIV Vaccine Trial Results: Hopes Dim for Struggling Field

Immunizations in a trial of Merck's HIV vaccine were stopped when it was determined that the vaccine was not working. There are now concerns that the vaccine may have increased the risk of HIV infection in some participants.

On September 18, 2007, t...

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Helping Your Immune System in the Fight Against HIV: A Talk With Steven Deeks, M.D.

About the Palm Project InterviewsTAG has conducted a series of interviews with leading scientists about the underlying pathogenesis of AIDS to gain insights into emerging lines of research and observations about the current research funding environme...

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Immune Activation in HIV Infection

"... no longer solely of interest to academic immunologists ..."

At the recent International AIDS Society conference in Sydney, Mike Lederman reminded attendees that abnormally high levels of immune activation were described in the first case report...

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Co-Receptor Conundrum: The Challenges of Turning Theory Into Reality

Since the late 1980s researchers have recognized that HIV isolates (viruses sampled from infected individuals) can be divided into one of two categories based on their ability to replicate in particular cells in the laboratory. Originally, a variety ...

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SMART Stops Stopping

The Strategies for the Management of Antiretroviral Therapy (SMART) trial was designed to investigate whether antiretroviral therapy could be used on an as-needed basis rather than continuously. The protocol involved interrupting therapy when the CD4...

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Immune-Based Therapies and Preventive Technologies Pipeline

The Current Landscape

The development of immune-based HIV therapies, preventive HIV vaccines, and microbicides is hampered by a common problem: the lack of any effective precedent. All three fields are currently attempting to build on a barren lands...