Latest by Richard Jefferys

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Emerging Regulatory Issues in HIV Cure Research

Over the past several years, there has been a welcome invigoration of the research effort to cure HIV infection. The mainstream media has picked up on this development, and stories about putative or possible cures are appearing more frequently than i...

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Circulating Memory T Follicular Helper Cells Correlate With the Development of Broadly Neutralizing Antibody Responses Against HIV

A study published on September 12th by the journal Immunity ties together two emerging areas of HIV vaccine research. In recent years, scientists have discovered that a small proportion of chronically infected individuals develop antibody responses c...

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Lack of Efficacy and Safety Concerns Blight Adenovirus Vaccine Vectors

Vaccine vectors based on adenoviruses -- which are common in nature and cause severe colds -- were once viewed as promising for HIV and other intractable diseases due to their ability to induce antigen-specific CD8 T-cell responses in the majority of...

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Sad News Regarding Attempt to Duplicate the Cure Achieved in Timothy Brown

In April, doctors at the University of Minnesota announced that they were attempting to reproduce the cure achieved in Timothy Brown in a 12-year old boy with HIV and leukemia who required a stem cell transplant. Due to the challenges associated with...

Undetectable Is Not Always Enough: Immunologic Nonresponders Face Increased Risk of Illness, but Lack Therapeutic Options Img

Undetectable Is Not Always Enough: Immunologic Nonresponders Face Increased Risk of Illness, but Lack Therapeutic Options

What is there to do with the small subset of positive people on treatment -- called immunologic nonresponders -- who reach undetectable but don't get a healthy boost in their CD4 count?

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Can a Route to Broadly Neutralizing Antibodies Be Traced?

In recent years, new technologies have facilitated the discovery of an expanding number of antibodies capable of neutralizing a broad array of primary HIV isolates from different clades. As covered previously on the blog, these broadly neutralizing a...

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CMV Vector Vaccination Leads to Apparent Clearance of SIV Infection

Louis Picker from the Vaccine and Gene Therapy Institute at Oregon Health & Science University gave an update on results obtained in macaques with a CMV-based vaccine against SIV (abstract, webcast -- fourth in session). As Picker has shown in publis...

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Gene Modification of Virus-Specific CD4 T Cells

Patrick Younan from the Fred Hutchinson Cancer Research Center delivered an interesting talk about transplantation of gene-modified stem cells in pigtailed macaques (abstract, webcast -- third in session). The experiment used lentiviral vectors to de...

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Probiotic/Prebiotic Supplement Combination Shows Benefits in SIV-Infected Pigtailed Macaques

Over the years, a number of small studies have been published suggesting that there might be benefits associated with probiotic and/or prebiotic supplementation in people with HIV infection. Probiotics typically comprise live microbes that play a key...

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Children (Ages 0-17)

Report of a Functional Cure in an HIV-Infected Infant

On Monday March 4th at the Conference on Retroviruses and Opportunistic Infections (CROI) in Atlanta, details were presented on a case of a potential "functional cure" of HIV infection in an infant. The story has already broken widely in the media du...