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Latest by Richard Jefferys

HIV Reservoir Measurements and Viral Load Rebound After ART Interruption Img

HIV Reservoir Measurements and Viral Load Rebound After ART Interruption

To assist in the search for therapies that might contribute to curing HIV infection, scientists are seeking to identify biomarkers that are associated with control of viral load after an antiretroviral therapy (ART) interruption. If reliable predicto...

Case Report: Stem Cell Transplantation From CCR5 Delta-32 Homozygous Donor Selects for X4-Tropic HIV Img

Case Report: Stem Cell Transplantation From CCR5 Delta-32 Homozygous Donor Selects for X4-Tropic HIV

A letter published in the New England Journal of Medicine describes the outcome of a recent attempt to repeat the HIV cure achieved in Timothy Brown.

Stemming the Flow From HIV Reservoirs With Neutralizing Antibodies Img

Stemming the Flow From HIV Reservoirs With Neutralizing Antibodies

Two recent papers address the potential of broadly neutralizing antibodies (bNAbs) to decrease HIV rebound from persistent reservoirs. In the journal Cell, Ariel Halper-Stromberg and colleagues report the results of experiments conducted in the human...

Latent HIV Reservoirs Appear to Be Reactivated by Compound Found in Plant Img

Latent HIV Reservoirs Appear to Be Reactivated by Compound Found in Plant

Ingenol B (Ing B), a compound found in a tropical plant, shows promise in reactivating the latent HIV reservoirs. More research on the compound could provide innovative approaches to eradicate the virus.

Early HIV Treatment in Infants: The Canadian Experience Img
Children (Ages 0-17)

Early HIV Treatment in Infants: The Canadian Experience

Initial results from the Canadian pediatric HIV research mentioned in a recent blog post were published in Clinical Infectious Diseases on June 9th. The paper notes that Canada's three pediatric HIV care institutions have a longstanding policy of adm...

Wrestling With the Implications of the Mississippi Case Img
Children (Ages 0-17)

Wrestling With the Implications of the Mississippi Case

Understandably, there has been extensive media coverage of the announcement that HIV has rebounded in the "Mississippi child." Although a full discussion of the implications will take time, there are some points that may be worth noting now, accordin...

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More on the Links Between the CD4/CD8 Ratio, Immunological Perturbations, and Risk of Illness and Death

Since posting recently about studies investigating the relevance of the CD4/CD8 ratio in the antiretroviral therapy era, several new papers and presentations have provided more information on the topic. Last week in the open access journal PLoS Patho...

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Conference Coverage

Catching Up With Pathogenesis and Cure Research From CROI 2014

In addition to studies covered in prior posts (a possible second pediatric cure case, Sangamo's gene therapy and limitations of latency-reversing agents), CROI 2014 featured a smorgasbord of presentations related to pathogenesis and cure research. We...

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Studies Highlight Shortcomings of Latency-Reversing Agents

The persistence of a latent form of HIV integrated into the genome of long-lived cells, particularly memory CD4 T cells, is considered the most significant barrier to curing the infection. A key element of cure research is the pursuit of strategies c...

Updates on SB728-T, a CCR5-Targeting Gene Therapy Img
Conference Coverage

Updates on SB728-T, a CCR5-Targeting Gene Therapy

Recently there have been two widely publicised updates relating to SB728-T, a gene therapy for HIV infection developed by Sangamo BioSciences.

On Wednesday March 5th the New England Journal of Medicine (NEJM) published results from a phase I study c...