https://www.thebodypro.com/author/richard-jefferys

Latest by Richard Jefferys

Enhancing Immunity: Manipulating the Immune System to Tackle HIV Img

Enhancing Immunity: Manipulating the Immune System to Tackle HIV

In the search for a cure, multiple clinical trials are investigating whether immune-based approaches can deliver the "kill" in "kick and kill."

Latent Tendencies: New Strategies Target Dormant HIV Img

Latent Tendencies: New Strategies Target Dormant HIV

A major focus of HIV cure research is on reversing HIV latency -- essentially switching on the latent virus's DNA machinery so that it starts making proteins.

Measuring the HIV Reservoir: Current Tests for Sizing Up Viral Hideouts Img

Measuring the HIV Reservoir: Current Tests for Sizing Up Viral Hideouts

There are a variety of technologies available to accurately quantify the latent HIV reservoir, but each has pros and cons.

The Challenge of Defining an HIV Cure Img

The Challenge of Defining an HIV Cure

As the research effort to develop a safe, effective, broadly accessible HIV cure expands, the issue of how to measure success remains central.

Additional Remission Cases Published Img

Additional Remission Cases Published

Two recent case reports of temporary HIV remission, first presented at this year's CROI and IAS conferences, have now been published in the open access journal PLoS Medicine.

HIV Latency: Trapped in Transition, Lurking in Treg Img

HIV Latency: Trapped in Transition, Lurking in Treg

New research supports the theory that HIV latency occurs when HIV infects a CD4 T cell that is in the process of transitioning from an activated state to a resting state.

Locking Down Latent HIV Img

Locking Down Latent HIV

Researchers are flipping the idea of latency reversal on its head. Their approach -- which they have dubbed block and lock -- involves trying to imprison latent HIV in a way that prevents it from ever reactivating.

Estimating the Total Size of the HIV Reservoir Img

Estimating the Total Size of the HIV Reservoir

Researchers estimated a total body burden of as many as seven million cells expressing HIV RNA at any given time in tissues, despite viral load suppression to undetectable levels in the blood.

Effects of the Anti-Inflammatory Antibody Canakinumab on Heart Disease and Cancer: Implications for HIV? Img

Effects of the Anti-Inflammatory Antibody Canakinumab on Heart Disease and Cancer: Implications for HIV?

New study results prompt the question of whether canakinumab or other anti-inflammatories could have salutary clinical effects in HIV-positive people.

Report From the 2017 IAS HIV Cure and Cancer Forum Img
Cancer

Report From the 2017 IAS HIV Cure and Cancer Forum

Many approaches being pursued as cancer therapeutics are also being studied in the context of HIV cure research, including immune checkpoint inhibitors, cytokine therapies, genetically modified chimeric antigen receptor (CAR) T cells and other gene t...