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Latest by Polly Clayden

Long-Acting ART for Children Is a Deferred Priority Despite Achievable Dosing Img
Children (Ages 0-17)

Long-Acting ART for Children Is a Deferred Priority Despite Achievable Dosing

Optimal doses of long-acting injectable antiretrovirals cabotegravir and rilpivirine were predicted for different weight bands in children and adolescents.

No Transmissions From Breastfeeding in Tanzania Cohort From Mothers With Undetectable Viral Load Img
Children (Ages 0-17)

No Transmissions From Breastfeeding in Tanzania Cohort From Mothers With Undetectable Viral Load

No HIV-exposed infants who were negative at birth, whose mothers started ART before delivery, had suppressed viral loads, and exclusively breastfed, were HIV positive after breastfeeding, in a rural African cohort.

Twice-Daily Tenofovir Alafenamide Dose Might Overcome Interaction With Rifampicin Img
Tuberculosis

Twice-Daily Tenofovir Alafenamide Dose Might Overcome Interaction With Rifampicin

Twice-daily tenofovir alafenamide plus rifampicin provided similar exposures to once-daily TAF in a pharmacokinetic study. This strategy might be a suitable option for people with HIV/TB coinfection.

Chewable Raltegravir Tablets Can Be Crushed and Dispersed in Liquid for Young Children Img
Children (Ages 0-17)

Chewable Raltegravir Tablets Can Be Crushed and Dispersed in Liquid for Young Children

Chewable raltegravir tablets can be crushed and stirred until dispersed in water, apple juice or breast milk and given to younger children according to WHO weight bands.

Dolutegravir Outperforms Lopinavir/Ritonavir Second-Line: Interim Results From the DAWNING Study Img
IAS (International AIDS Society) Conference

Dolutegravir Outperforms Lopinavir/Ritonavir Second-Line: Interim Results From the DAWNING Study

Dolutegravir (DTG) was superior to lopinavir/ritonavir (LPV/r) in a comparison of DTG-based regimen versus the WHO-recommended second-line regimen.

Increased Risk of ART Failure After Low-Level Viraemia in a Large South African Cohort Img
South Africa

Increased Risk of ART Failure After Low-Level Viraemia in a Large South African Cohort

Viral load cut-off as defined by WHO guidelines fails to identify a significant number of HIV positive people at risk for virological failure, according to findings from South Africa presented at the 11th INTEREST workshop.

Dolutegravir Pharmacokinetics in Pregnancy Img

Dolutegravir Pharmacokinetics in Pregnancy

Dolutegravir exposure and trough concentrations in third trimester of pregnancy appear to be similar to postpartum.

WHO Adds Dolutegravir and PrEP to Updated Essential Medicine List Img
News

WHO Adds Dolutegravir and PrEP to Updated Essential Medicine List

The World Health Organization's Essential Medicines List is used by many countries to help increase access to medicines and guide decisions on which ones should be made available to their populations.

World Health Organization Pediatric Dosing Tool Img
CROI (Conference on Retroviruses and Opportunistic Infections)

World Health Organization Pediatric Dosing Tool

A pediatric dosing tool developed by the World Health Organization might assist in the design of clinical trials for dosing in children.

Increased Risk of IRIS With Integrase Inhibitors Reported in Two Studies Img
CROI (Conference on Retroviruses and Opportunistic Infections)

Increased Risk of IRIS With Integrase Inhibitors Reported in Two Studies

Two cohort studies showed a higher risk of IRIS with integrase inhibitor-based ART than with other regimens.