Latest by Polly Clayden
Optimal doses of long-acting injectable antiretrovirals cabotegravir and rilpivirine were predicted for different weight bands in children and adolescents.
No HIV-exposed infants who were negative at birth, whose mothers started ART before delivery, had suppressed viral loads, and exclusively breastfed, were HIV positive after breastfeeding, in a rural African cohort.
Twice-daily tenofovir alafenamide plus rifampicin provided similar exposures to once-daily TAF in a pharmacokinetic study. This strategy might be a suitable option for people with HIV/TB coinfection.
Chewable raltegravir tablets can be crushed and stirred until dispersed in water, apple juice or breast milk and given to younger children according to WHO weight bands.
Dolutegravir (DTG) was superior to lopinavir/ritonavir (LPV/r) in a comparison of DTG-based regimen versus the WHO-recommended second-line regimen.
Viral load cut-off as defined by WHO guidelines fails to identify a significant number of HIV positive people at risk for virological failure, according to findings from South Africa presented at the 11th INTEREST workshop.
Dolutegravir exposure and trough concentrations in third trimester of pregnancy appear to be similar to postpartum.
The World Health Organization's Essential Medicines List is used by many countries to help increase access to medicines and guide decisions on which ones should be made available to their populations.
A pediatric dosing tool developed by the World Health Organization might assist in the design of clinical trials for dosing in children.
Two cohort studies showed a higher risk of IRIS with integrase inhibitor-based ART than with other regimens.