Latest by Thanes J. Vanig, M.D.

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Initiation of HAART May Increase Free Testosterone Levels and Fat-Free Mass


Probably the most common endocrine abnormality seen in men with HIV is hypogonadism (or low testosterone levels). Symptoms may include fatigue, weight loss, muscle mass loss, depression and low libido. This problem sometimes goes undiagno...

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Protease Inhibitors Appear More Likely to Cause Atherosclerosis Than NNRTIs

Most protease inhibitors (PIs) have been associated with abnormal lipid profiles and insulin resistance, whereas better lipid profiles (such as an increase in high-density lipoprotein [HDL]) are seen with non-nucleoside reverse transcriptase inhibi...

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Tipranavir Reduces Concentrations of Other Protease Inhibitors

All protease inhibitors (PIs) are substrates, as well as inducers or inhibitors, of the CYP3A4 system. Combining PIs can either increase or decrease the concentration of each drug. While ritonavir (RTV, Norvir), a potent CYP3A4 inhibitor, is widely u...

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Patients Beginning HAART With a Low CD4+ Cell Count Respond Well

In the era of HAART, countless studies have shown that both HIV-related morbidity and mortality have dramatically decreased. Most patients today are diagnosed early and therapy is initiated before they develop any opportunistic infections (OIs). Howe...