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Latest by Frank S. Rhame, M.D.

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Zidovudine/Lamivudine/Abacavir May Be Effective Alone for Induction Maintenance

Background

"Induction maintenance" is a treatment strategy that uses a more potent regimen initially and drops back to a less potent (and hopefully less toxic) regimen after the initial response. It is modeled on cancer chemotherapy, which has been ...

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Confort Study Supports Switch From Protease Inhibitor to Nevirapine

Background

It is clear now that all but the most recently approved protease inhibitors (PIs) cause more gastrointestinal side effects and adverse effects on lipid profiles during treatment than the non-nucleoside reverse transcriptase inhibitors (NN...

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Lamivudine/Abacavir Is an Effective Nucleoside Backbone in Combinations Other Than With Tenofovir

Background

At the 2nd International AIDS Society Conference in Paris in the summer of 2003, we first learned of the unexpected weakness of the triple-nucleoside regimen consisting of tenofovir (TDF, Viread) plus lamivudine (3TC, Epivir) plus abacavi...

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Cancer

Anal Cancer Still a Risk to HIV-Infected Men Who Have Receptive Anal Intercourse

The incidence of anal squamous cell carcinoma is higher in gay men, presumably because receptive anal intercourse increases exposure to and infection by human papillomavirus (HPV). There are multiple types of HPV. The early changes in the rectal muco...

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Cancer

Non-Hodgkin's Lymphoma Rates Lower in HAART-Treated Patients

Background

Untreated HIV infection confers a huge increase in the incidence of non-Hodgkin's lymphoma (NHL). Understanding the extent to which HAART mitigates this risk is of vital importance to HIV-infected persons.

Details of This Study

Waterson...

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Older Adults (Ages 50+)

Aging HIV-Infected Population at Risk for Malignancies Despite HAART

There were approximately 20 presentations at this conference on the causes of death in HIV-infected persons. About half the presentations were from resource-poor areas. These studies presented information quite familiar to those of us who were studyi...