https://www.thebodypro.com/article/weighing-risks-of-tdfftc-prep-side-effects-in-peop
PrEP (HIV Pre-Exposure Prophylaxis)

Weighing Risks of TDF/FTC PrEP Side Effects in People Without HIV

    Figure 1. Possible Mechanisms of Kidney and Bone Toxicity With TDF
    Figure 1. Possible Mechanisms of Kidney and Bone Toxicity With TDF Research suggests possible mechanisms for the much-studied impact of tenofovir disoproxil fumarate (TDF) on kidney and bone mineral density: Kohler JJ, Hosseini SH, Hoying-Brandt A, et al. Tenofovir renal toxicity targets mitochondria of renal proximal tubules. Lab Invest. 2009;89:513-519; Grigsby IF, Pham L, Mansky LM, Gopalakrishnan R, Mansky KC. Tenofovir-associated bone density loss. Clin Risk Manag. 2010;6:41-47. Kidney and spine illustrations from Servier Medical Art.
    Figure 2. Increased Risk of Kidney Toxicity With Each Year of TDF
    Figure 2. Increased Risk of Kidney Toxicity With Each Year of TDF Each year of TDF therapy independently raised the risk of three kidney dysfunction endpoints in a study of 10,841 HIV-positive US veterans, 98% of them men and half black.17 Endpoints are defined in the text, and risks are calculated as hazard ratios (proteinuria 1.34, 95% CI 1.25 to 1.45, P < 0.0001; rapid decline in kidney function 1.11, 95% CI 1.03 to 1.18, P = 0.0033; chronic kidney disease 1.33, 95% CI 1.18 to 1.51, P < 0.0001).
    Figure 3. New Fracture Rate by Age in US Gay Men With Versus Without HIV
    Figure 3. New Fracture Rate by Age in US Gay Men With Versus Without HIV Compared with US gay and bisexual men from 30 to 49 years old in the Multicenter AIDS Cohort Study, risk of new osteoporosisrelated fractures was higher in HIV-positive men than in HIV-negative men from 50 to 64 years old or 65 and older.33

    Mark Mascolini

    Mark Mascolini writes about HIV infection.

    The Center for AIDS Information & Advocacy

    The Center for AIDS Information & Advocacy