Research Shows 47% Reduction in STIs Among Gay Men Who Took Doxycycline After Sex

The antibiotic doxycycline, when taken within 72 hours of condomless sex, can reduce the risk of bacterial sexually transmitted infections (STIs) by 47%, new research presented at CROI this week showed. The antibiotic significantly reduced the number of chlamydia and syphilis infections, but did not reduce gonorrhea infections.

Jean-Michel Molina, the lead investigator of the IPERGAY on-demand PrEP study, presented results of the study conducted with a group of men who have sex with men (MSM) enrolled in the open-label portion of the IPERGAY study.

"We've seen in the last couple of years an increase in the number of STIs across Europe, North America and other countries including Australia, especially among MSM. It would be fair to acknowledge the increase actually pre-dates PrEP. Nevertheless, high rates of STIs have been reported among MSM on PrEP, and in the two European PrEP studies PROUD and IPERGAY, the proportion of men reporting an STI ranged from 41% [in IPERGAY] and 57% [in PROUD]. PrEP programs give a unique opportunity to foster research in testing, treatment and prevention of STIs," he said.

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