Pediatric HIV Cure Studied in Infant Monkeys

On behalf of IFARA, Fred Schaich spoke with Ann Chahroudi, M.D., Ph.D., about pediatric HIV cure research in monkey models that was presented at this year's International AIDS Conference. Her laboratory uses the monkey version of HIV, simian immunodeficiency virus, in infant rhesus macaques to study very early antiretroviral therapy and other approaches to a cure of HIV in very young children. The advantage of using a monkey model is that novel compounds and combination approaches can be researched with far less effort. In addition, anatomic reservoirs of latent HIV-infected cells that could not easily be studied in human babies are accessible in the monkey model. Just as in the early days of antiretroviral therapy development, no single cure strategy will likely be effective, Chahroudi predicted. Recent research has shown that HIV even develops resistance against broadly neutralizing antibodies (bNABs) if only one such agent is used. Using two bNABs together, however, significantly improves the protection against acquiring HIV that these novel agents confer.

Watch the video to learn more:

About the panelist:

  • Ann Chahroudi, M.D., Ph.D., Center for AIDS Research at Emory University, Atlanta, Georgia

The video above has been posted on with permission from our partners at the International Foundation for Alternative Research in AIDS (IFARA). Visit IFARA's website or YouTube channel to watch more video interviews from the conference, as well as earlier meetings.