2016 HIV Cure Update: Therapeutic Vaccines and Broadly Neutralizing Antibodies

2016 HIV Cure Update: Therapeutic Vaccines and Broadly Neutralizing Antibodies

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Researchers are exploring a number of different ways in which people living with HIV might be functionally cured of their infection. At ASM Microbe 2016, Dan H. Barouch, M.D., Ph.D., explained recent and upcoming studies involving two such strategies: therapeutic vaccines and broadly neutralizing antibodies. Most research into them has so far involved animal models, usually rhesus monkeys infected with SHIV, the simian version of HIV, but clinical trials starting later this year will examine both avenues for curing HIV in humans. In order to eradicate the virus from an animal's or a person's body, not only the portion of the virus that replicates itself, but also the viral reservoir that HIV establishes soon after infection must be targeted. This will likely require a combination of different strategies, Barouch said.

Researchers are exploring a number of different ways in which people living with HIV might be functionally cured of their infection. At ASM Microbe 2016, Dan H. Barouch, M.D., Ph.D., explained recent and upcoming studies involving two such strategies: therapeutic vaccines and broadly neutralizing antibodies. Most research into them has so far involved animal models, usually rhesus monkeys infected with SHIV, the simian version of HIV, but clinical trials starting later this year will examine both avenues for curing HIV in humans. In order to eradicate the virus from an animal's or a person's body, not only the portion of the virus that replicates itself, but also the viral reservoir that HIV establishes soon after infection must be targeted. This will likely require a combination of different strategies, Barouch said.

Credit: VCTStyle for iStock via Thinkstock.

Image Credit: VCTStyle for iStock via Thinkstock.