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BROWSE TOPICS IN CLINICAL MANAGEMENT:
Antiretroviral Therapy- Complications of HIV/HAART
- Research & Development
- Clinical Trials
- Quality of Life & Patient Care
Antiretroviral Therapy
Structured HIV Treatment Interruptions
Overview
- Changing Antiretroviral Therapy: Why, When, and How (June 2006)
A clinical overview from an online textbook of HIV disease from the University of California San Francisco and San Francisco General Hospital.
From HIV InSite - SMART Stops Stopping (April 2006)
A look at why the SMART study prematurely ended, and what it means for the future of HIV treatment interruptions.
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In TAGline, from Treatment Action Group - Questions and Answers About the SMART Study (January 18, 2006)
Highlighted information released after the cancellation of the largest study ever to examine the value of structured treatment interruptions.
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From U.S. National Institute of Allergy and Infectious Diseases - Structured Treatment Interruption Part I: Overview (February 11, 2004)
In The 11th Conference on Retroviruses and Opportunistic Infections, from The Body PRO - Structured Treatment Interruption Part II: Case Studies (February 11, 2004)
In The 11th Conference on Retroviruses and Opportunistic Infections, from The Body PRO - The Pros and Cons of Structured Treatment Interruptions (July 15, 2003)
In The 2nd International AIDS Society Conference on HIV Pathogenesis and Treatment, from The Body PRO - HAART Break: An Update on Structured Treatment Interruptions (July 2002)
In ACRIA Update, from AIDS Community Research Initiative of America - The Buzz: Structured Treatment Interruption and Immune Reconstitution (March/April 2002)
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In Positively Aware, from Test Positive Aware Network - NIH Seven-Day On-Off Trial May Reduce Drug Side Effects, Cost; Why It's Not Ready for Use (December 21, 2001)
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In AIDS Treatment News, from AIDS Treatment News - Structured Treatment Interruptions (November 2001)
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From Project Inform - Immunotherapy of HIV: On the Horizon? (October 2001)
The value of structured treatment interruption for those with acute HIV infection.
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In HEPP News, from Brown Medical School - Insights Into Treatment Interruptions for Patients with Early, Chronic, and Drug-Resistant HIV Disease (September 2001)
Summary of work from Marcus Altfeld, M.D., Mark Dybul, M.D., and Veronica Miller, Ph.D. by Tim Horn.
In The PRN Notebook - Structured Treatment Interruptions for the Management of HIV Infection
In Journal of the American Medical Association
Research/Trial Results
- Literature Citations for Structured Treatment Interruptions and HIV (Regularly Updated)
From U.S. National Institutes of Health - Interleukin-2 Ineffective in Maintaining Baseline CD4+ Cell Count During Treatment Interruption (February 6, 2008)
From The Body PRO - Resuming Treatment Partly Restores Health of Patients in SMART Study (February 3, 2008)
In 15th Conference on Retroviruses and Opportunistic Infections, from The Body PRO - Are Previous Treatment Interruptions Associated With Higher Viral Rebound Rates in Patients With Viral Suppression? (January 30, 2008)
In AIDS - TILT: A Look at the Role of Interleukin-2 in Treatment Interruption Leans Toward the Negative (February 28, 2007)
In Exclusive Coverage of the 14th Conference on Retroviruses and Opportunistic Infections, from The Body PRO - A Review of The SMART Study -- A Treatment Interruption Trial (February 2007)
From HIV JournalView: Top 10 HIV Medical Stories of 2006.
From The Body PRO - CD4+ Count-Guided Interruption of Antiretroviral Treatment (November 30, 2006)
In New England Journal of Medicine - SMART & Staccato: Two CD4-Guided Treatment Interruption Trials With Contradictory Results (August 17, 2006)
In XVI International AIDS Conference - Treatment Interruptions: SMART or Stupid? (Spring 2006)
An in-depth look at the data behind the SMART study -- and what lessons, if any, can be learned from the results.
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In ACRIA Update, from AIDS Community Research Initiative of America - Intermittent Treatment-Interruption Arm of Major African Study Is Halted (March 15, 2006)
From aidsmap.com - Community Sign-On Letter: Continue the SMART Trial (January 27, 2006)
From The Center for AIDS - International HIV/AIDS Trial Finds Continuous Antiretroviral Therapy Superior to Episodic Therapy (January 18, 2006)
The massive, international SMART trial is abruptly cancelled due to a twofold greater risk of progression to AIDS among people taking periodic treatment interruptions.
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From U.S. National Institute of Allergy and Infectious Diseases - Treatment Action Group Statement on the Termination of the SMART Study (January 18, 2006)
Many other types of HIV treatment interruptions may still have a benefit -- it is still too early to call them a failed strategy, the group says.
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From Treatment Action Group - Virologic Suppression Between Six and 18 Months on New Regimen Can Predict Long-Term Outcomes (December 16, 2005)
In addition, patients who previously had a treatment interruption appear less likely to succeed on their current regimen.
In The 45th Interscience Conference on Antimicrobial Agents and Chemotherapy - Case Report: Four-Year Treatment Break Reverses Woman's Lipohypertrophy, but Not Lipoatrophy (October 11, 2005)
From aidsmap.com - Efavirenz Clearance May Take Up to 8 Weeks, Case Report Warns; Implications for Treatment Interruption (September 28, 2005)
From aidsmap.com - Treatment Interruption Less Successful When Nadir CD4 Count Is Below 200, Study Finds; Incomplete Post-Interruption Immune Recovery Is Concern (September 2005)
In AIDS Patient Care and STDs - NNRTIs Have a Greater Risk of Resistance Than PIs When Used in Regimens After Treatment Break (August 26, 2005)
From aidsmap.com - Lamivudine Monotherapy Better Than Treatment Interruption in Rescue Patients With M184V (July 27, 2005)
In The 3rd International AIDS Society Conference on HIV Pathogenesis and Treatment - Comparing a Treatment Interruption With or Without Interleukin-2 in Delaying a Falling CD4+ Cell Count (February 25, 2005)
In The 12th Conference on Retroviruses and Opportunistic Infections, from The Body PRO - Supervised Treatment Interruptions After Successful HAART: Strategy Usually Not Successful Over Long Term (December 31, 2004)
In AIDS Treatment News, from AIDS Treatment News - Weekend Treatment Interruptions for Certain Well-Controlled Patients: Interview With Cal Cohen, M.D. (December 31, 2004)
In AIDS Treatment News, from AIDS Treatment News - HIV JournalView: When to Stop Antiretroviral Therapy? (December 2004)
A JAIDS study finds that treatment discontinuation is safe in some patients with CD4+ cell counts over 250.
From The Body PRO - Treatment Interruption May Work for People With Pre-HAART CD4 Counts Over 250 (October 26, 2004)
From aidsmap.com - CD4-Guided Pulse Therapy; Induction/Maintenance Therapy: Research From AIDS 2004 (September 2004)
A list of studies examining these two therapy-sparing approaches to HIV treatment.
In TAGline, from Treatment Action Group - French Researchers Question Benefit of Lifelong Antiretroviral Treatment (August 2004)
A small, limited study suggests that after three years of use, HAART may reach the apex of its immunologic benefit.
In TAGline, from Treatment Action Group - Five Days On, 2 Days Off: A Pilot Study on Innovative Treatment of HIV Infection (July 13, 2004)
In The XV International AIDS Conference, from The Body PRO - Weekly Cycles of Once-Daily Anti-HIV Drugs Could Reduce Cost of HIV Treatment (May 20, 2004)
From U.S. National Institute of Allergy and Infectious Diseases - Benefit of Treatment Interruption in HIV-Infected Patients With Multiple Therapeutic Failures: A Randomized Controlled Trial (March 12, 2004)
Contrary to earlier findings, this study suggests interruptions can be successful in multi-drug-resistant patients.
From Johns Hopkins AIDS Service - Structured Treatment Interruption Part I: Overview (February 11, 2004)
In The 11th Conference on Retroviruses and Opportunistic Infections, from The Body PRO - Structured Treatment Interruption Part II: Case Studies (February 11, 2004)
In The 11th Conference on Retroviruses and Opportunistic Infections, from The Body PRO - Interruption of Treatment Is Safe for Those Who Started Too Early (December 2003/January 2004)
A recent European study bolsters the idea that HIV-positive people who started treatment with CD4 counts over 350 can safely stop.
From HIV i-Base - Failures of One Week On, One Week Off Antiretroviral Therapies in a Randomized Trial (November 2003)
Abstract of a study in the journal AIDS.
In IAPAC Monthly, from International Association of Physicians in AIDS Care - CD4-Guided Treatment Interruptions: A New Therapeutic Strategy (September 15, 2003)
In The 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy, from The Body PRO - Negative Impact of Drug Holidays in HIV-Infected Patients on NNRTIs (September 15, 2003)
In The 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy, from The Body PRO - Structured Treatment Interruptions Successful With Patients Who Have High CD4 Counts (September 14, 2003)
In The 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy, from The Body PRO - Treatment Interruption: Study Found Poor Result for Highly Treated, Highly Resistant Patients (September 12, 2003)
In AIDS Treatment News, from AIDS Treatment News - Treatment Interruption Shows No Benefit in Drug-Resistant HIV Infection (August 27, 2003)
From U.S. National Institute of Allergy and Infectious Diseases - Intermittent HIV Therapy Still Not a Viable Option (July 16, 2003)
In The 2nd International AIDS Society Conference on HIV Pathogenesis and Treatment, from The Body PRO - Structured Treatment Interruption Failure in Treatment-Experienced Patients (July 15, 2003)
In The 2nd International AIDS Society Conference on HIV Pathogenesis and Treatment, from The Body PRO - An Interview With Dr. Cal Cohen on Highlights From the 10th Conference on Retroviruses and Opportunistic Infections (April 4, 2003)
In AIDS Treatment News, from AIDS Treatment News - Structured Treatment Interruption (STI) (March 3, 2003)
Part of HIV InSite's coverage of the 10th Conference on Retroviruses and Opportunistic Infections.
From HIV InSite - Key Therapeutic Decisions in Managing HIV Infection (Spring 2003)
An update on when to start, when to switch and when to stop, from STEP's conference review of Retrovirus 2003.
In STEP Perspective, from Seattle Treatment Education Project - Structured Treatment Interruption as a Long-Term Treatment Strategy (Spring 2003)
From STEP's conference review of Retrovirus 2003.
In STEP Perspective, from Seattle Treatment Education Project - Structured Treatment Interruption to Increase Response to Salvage Therapy (Spring 2003)
From STEP's conference review of Retrovirus 2003.
In STEP Perspective, from Seattle Treatment Education Project - Benefit of Interrupting AIDS Drugs Is Debated; New Research Supports Both Sides (February 13, 2003)
In CDC HIV/Hepatitis/STD/TB Prevention News Update, from U.S. Centers for Disease Control and Prevention - Swiss-Spanish Intermittent Treatment Trial: A Qualified Failure? (January 29, 2003)
The results from the largest structured treatment interruption trial to date may not be as terrible as advertised.
In TAGline, from Treatment Action Group - Salvage Strategies and STI at the 10th Annual Retrovirus Conference (January/February 2003)
In GMHC Treatment Issues, from Gay Men's Health Crisis - Research From the 42nd ICAAC: Predicting Rebounds, Predicting Death (December 2002)
In IAPAC Monthly, from International Association of Physicians in AIDS Care - Predictors of Long-Term Response to Therapy Resumption After Treatment Interruption in HIV-1 Infected Patients Failing Antiretroviral Therapy (November 19, 2002)
In The 6th International Congress on Drug Therapy in HIV Infection, from The Body PRO - Shift in HIV-1 Resistance After Treatment Interruption in Patients With Virological Failure and Antiviral Effect Following Trizivir Plus Efavirenz (AZLF3003 Study) (November 19, 2002)
In The 6th International Congress on Drug Therapy in HIV Infection, from The Body PRO - Treatment Interruptions (November 18, 2002)
In The 6th International Congress on Drug Therapy in HIV Infection, from The Body PRO - Antiviral Therapy 2002 (November 17, 2002)
In The 6th International Congress on Drug Therapy in HIV Infection, from The Body PRO - Altered States (November 2002)
An overview of results from the 2002 Swiss-Spanish Intermittent Treatment Trial.
In TAGline, from Treatment Action Group - Supervised Treatment Interruption in an Urban HIV Clinical Practice: A Prospective Analysis (October 26, 2002)
In 40th Annual Meeting of the Infectious Diseases Society of America, from The Body PRO - Key T-Cell Subset Loses Efficacy During Structured Treatment Interruptions (October 11, 2002)
In CDC HIV/Hepatitis/STD/TB Prevention News Update, from U.S. Centers for Disease Control and Prevention - "Drug Holidays" Not Beneficial for Fighting HIV (September 25, 2002)
In CDC HIV/Hepatitis/STD/TB Prevention News Update, from U.S. Centers for Disease Control and Prevention - HAART Interruption Strategies: How, When, and Why? (September 2002)
A review of the latest research.
In The PRN Notebook - STIs in Chronic Infection: Predicting Success (September 2002)
In TAGline, from Treatment Action Group - Long-Term Interruption of HIV Treatment May Be Safe in Certain Patients (August 29, 2002)
In CDC HIV/Hepatitis/STD/TB Prevention News Update, from U.S. Centers for Disease Control and Prevention - Digging Deeper at the Resistance Workshop (August 14, 2002)
Key clinical findings from July's XI International HIV Drug Resistance Workshop.
From International AIDS Society - Drug Halt Can Reduce Resistance in Late-Stage AIDS (July 11, 2002)
In CDC HIV/Hepatitis/STD/TB Prevention News Update, from U.S. Centers for Disease Control and Prevention - Dynamics of Viral Rebound in Plasma and Semen After Stopping Effective Antiretroviral Therapy (July 11, 2002)
In The XIV International AIDS Conference, from The Body PRO - Strategies to Prevent Loss of CD4+ and Onset of Resistance During Treatment Interruptions (July 11, 2002)
In The XIV International AIDS Conference, from The Body PRO - Treatment Interruptions: A Summary of the Data to Date (July 11, 2002)
In The XIV International AIDS Conference, from The Body PRO - Special Retrovirus Update: Structured Treatment Interruptions (March 28, 2002)
To read PDF, click here
In STEP Ezine, from Seattle Treatment Education Project - 9th Retrovirus Conference Coverage: Structured Treatment Interruptions (Spring 2002)
In STEP Perspective, from Seattle Treatment Education Project - Anti-HIV Therapy Update: STI and Third-Line Therapy (March 2002)
In Project Inform Perspective, from Project Inform - Strategic Treatment Interruptions: Where Are We? (February 26, 2002)
In The 9th Conference on Retroviruses and Opportunistic Infections, from The Body PRO - SSITT: A Prospective Trial of Treatment Interruptions in HIV Infection (February 25, 2002)
In The 9th Conference on Retroviruses and Opportunistic Infections, from The Body PRO - Long-Term Effects of Treatment Interruptions: 18-Month Evaluation of a Controlled Trial in >300 HIV-Positive Patients (December 18, 2001)
In 41st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2001), from The Body PRO - Predictors of Virologic and Immunologic Success Post Treatment Interruption (TI) in Patients with Chronic HIV Infection (December 18, 2001)
In 41st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2001), from The Body PRO - Structured Treatment Interruptions (STI) in Patients Receiving HAART Since Primary HIV-1 Infection (PHI): Spontaneous Control of Viremia in Almost Half of Cases After the First Two Cycles Off Therapy (December 18, 2001)
In 41st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2001), from The Body PRO - STI in Patients with Incomplete Viral Suppression (December 16, 2001)
In 41st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2001), from The Body PRO - Use of Structured Treatment Interruptions in Primary Infections (December 16, 2001)
In 41st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2001), from The Body PRO - 7-Day-On, 7-Day-Off Regimen Could Reduce Cost, Toxicities of HIV Therapy (December 3, 2001)
From U.S. National Institute of Allergy and Infectious Diseases - Structured Treatment Interruption: Panacea or Pandora? (October 27, 2001)
In 39th Annual Meeting of the Infectious Diseases Society of America, from The Body PRO - Treatment Interruption: Erroneous Press Report (July 27, 2001)
To read PDF, click here
In AIDS Treatment News, from AIDS Treatment News - Effects of Prolonged Discontinuation of Successful Antiretroviral Therapy (July 9, 2001)
In The 1st International AIDS Society Conference on HIV Pathogenesis and Treatment, from The Body PRO - CD4 Cell Response During Lengthy or Unsupervised Treatment Interruptions (Summer/Autumn 2001)
In Bulletin of Experimental Treatments for AIDS, from San Francisco AIDS Foundation - Drug Holidays, Structured Treatment Interruptions, and Structured Intermittent Therapy (Februray 19, 2001)
In The 2001 National Conference on African Americans and AIDS, from The Body PRO - Virologic and Immunologic Consequences of Discontinuing Combination Antiretroviral-Drug Therapy in HIV-Infected Patients With Detectable Viremia (February 15, 2001)
In New England Journal of Medicine - New Insights Into Viral Reservoirs and HIV Treatment Interruptions (February 7, 2001)
In The 8th Conference on Retroviruses and Opportunistic Infections, from The Body PRO - Structured Treatment Interruption: Novel Strategy or Oxymoron? (February 6, 2001)
Summaries of two notable studies presented during a symposium on STIs.
In The 8th Conference on Retroviruses and Opportunistic Infections, from The Body PRO - The Effect of Treatment Interruption in Patients With Virologic Failure: Results From a Multi-Cohort Collaborative Study (February 6, 2001)
In The 8th Conference on Retroviruses and Opportunistic Infections, from The Body PRO - Two Studies Examine Value of Intermittent Treatment Interruptions (February 6, 2001)
In The 8th Conference on Retroviruses and Opportunistic Infections, from The Body PRO - Structured Treatment Interruptions Workshop Summary (January 31, 2001)
To read PDF, click here
From Project Inform
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