Mycobacterium Avium Complex (MAC) & HIV/AIDS

Overview | Treatment | Research

Preferred Therapy and Duration
Recommendation from the U.S. Centers for Disease Control and Prevention

At least 2 drugs as initial therapy
Clarithromycin 500 mg PO BID (AI) and ethambutol 15 mg/kg body weight PO QD (AI)

For full recommendations, click here

Overview

You Can Prevent MAC (Disseminated Mycobacterium Avium Complex Disease) (June 21, 2007)
A patient-education fact sheet.
From U.S. Centers for Disease Control and Prevention
Mycobacterium Avium Complex (2006)
A chapter from Clinical Manual for Management of the HIV-Infected Adult.
From AIDS Education & Training Centers National Resource Center
Mycobacterium Avium Complex and Atypical Mycobacterial Infections in the Setting of HIV Infection (January 2006)
A clinical overview from the comprehensive, online textbook of HIV disease from the University of California San Francisco and San Francisco General Hospital.
From HIV InSite
Opportunistic Infection Prophylaxis: Disseminated Mycobacterium Avium Complex (2006)
A section from Clinical Manual for Management of the HIV-Infected Adult..
From AIDS Education & Training Centers National Resource Center
Treating Opportunistic Infections Among HIV-Infected Adults and Adolescents: Mycobacterial Infections (December 2004)
55 slides covering MTB and MAC; available only in PowerPoint.
From AETC National Resource Center
Mycobacterium Avium Complex (MAC) Fact Sheet (November 2004)
To read PDF, click here.
From Project Inform
Chart of Opportunistic Infections: Mycobacterium Avium Complex (October 2001)
From Project Inform
Discontinuation of Prophylaxis Against Mycobacterium Avium Complex Disease in HIV-Infected Patients Who Have a Response to Antiretroviral Therapy (April 13, 2000)
In New England Journal of Medicine

Treatment

FDA Issues "Black Box" Warning for Cipro, Similar Drugs (July 9, 2008)
From Project Inform
Disseminated Mycobacterium avium Complex Disease (December 17, 2004)
A chapter from "Treating Opportunistic Infections Among HIV-Infected Adults and Adolescents" guidelines.
To read PDF, click here.
In Morbidity and Mortality Weekly Report, from U.S. Centers for Disease Control and Prevention

Research

Mycobacterium Avium Complex Immune Reconstitution Inflammatory Syndrome: Long Term Outcomes (October 15, 2007)
In Journal of Translational Medicine
Discontinuing Primary and Secondary PCP Prophylaxis in Patients Who Have Increased CD4 Counts in Response to Antiretroviral Therapy: Preliminary Results -- ACTG 888 (January 31, 2000)
In The 7th Conference on Retroviruses and Opportunistic Infections, from TheBodyPRO.com
Prevention of Opportunistic Infections Other Than Mycobacterium Avium Complex in a Randomized, Placebo-Controlled Trial of Azithromycin (AZ) Prophylaxis in Subjects With Increases in CD4 Cells on Antiretroviral Therapy -- Preliminary Results (January 31, 2000)
In The 7th Conference on Retroviruses and Opportunistic Infections, from TheBodyPRO.com
Frequency of Isolation of M. Avium Complex From Marrow in Patients Suspected of Disseminated MAC but With Negative Blood Cultures (January 31, 2000)
In The 7th Conference on Retroviruses and Opportunistic Infections, from TheBodyPRO.com

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