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BROWSE TOPICS IN CLINICAL MANAGEMENT:
Antiretroviral Therapy- Complications of HIV/HAART
- Research & Development
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ShareMetabolic Complications: Research
See also: Metabolic Complications Overview
General Lipodystrophy Research
- ACTG 5202 Substudy Finds Little Lipoatrophy but Signs of Bone Loss Across the Board; Devil Is in the Details (February 19, 2010)
A discussion with Grace McComsey, M.D.
In The 17th Conference on Retroviruses and Opportunistic Infections, from The Body PRO - Can Carnitine Reduce Diabetes Risk and Improve Body Shape? (September 28, 2009)
From Canadian AIDS Treatment Information Exchange - Leptin Injections May Help HIVers With Lipoatrophy, Other Metabolic Problems, According to Small Study (April 2009)
The full text of a study published in the Journal of Clinical Endocrinology & Metabolism.
From National AIDS Treatment Advocacy Project - Whither Recombinant Human Leptin Treatment for HIV-Associated Lipoatrophy and the Metabolic Syndrome? (April 2009)
Christos Mantzoros, M.D., an associate professor at Harvard Medical School, offers his take on whether there's a future for leptin replacement as a treatment for metabolic complications in HIV-infected patients. (Editorial originally published in the Journal of Clinical Endocrinology & Metabolism.)
From National AIDS Treatment Advocacy Project - HIV/HCV-Coinfected Patients Appear More Likely Than HIV-Monoinfected Patients to Develop Insulin Resistance After Initiating HAART (February 5, 2008)
From The Body PRO - Body Fat Changes Becoming Less Common as HIVers Use Fat-Friendlier Meds, Study Finds (January 23, 2008)
In HIV Medicine - Study May Disprove Link Between HIV/Hep C Coinfection and Some Metabolic Problems (May 21, 2007)
A pair of new U.S. studies appears to contradict long-held concerns that HIV/hepatitis C-coinfected people have a higher risk of diabetes and lipoatrophy (fat loss).
From aidsmap.com
- Literature Citations for the Diagnosis of Lipodystrophy/Lipoatrophy in HIV-Positive Patients (Regularly Updated)
From U.S. National Institutes of Health - Literature Citations for the Management of Metabolic Disorders in HIV-Positive Patients (Regularly Updated)
From U.S. National Institutes of Health - Literature Citations for the Treatment of Lipodystrophy/Lipoatrophy in HIV-Positive Patients (Regularly Updated)
From U.S. National Institutes of Health - Increased Fat Consumption Observed in People With HIV With High Cholesterol (August 22, 2007)
From aidsmap.com - NRTIs Exposure Increases Diabetes Risk in HIV-Infected Women Over Time (August 20, 2007)
In AIDS - Dietary Intervention When Starting HAART Prevents the Increase in Lipids Independently of Drug Regimen: A Randomized Trial (July 25, 2007)
From International AIDS Society - Switch Studies (SWEET and BICOMBO) Explore Metabolic Issues (July 25, 2007)
In The 4th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention, from The Body PRO - The Role of Nucleoside Analogs in the Development of Insulin Resistance (July 24, 2007)
NRTIs to date have been thought to contribute to insulin resistance mainly via induction of lipoatrophy. The authors of this paper put forth another potential mechanism based on their findings: that is, zidovudine (AZT, Retrovir)-mediated mitochondrial toxicity in skeletal muscle, adipocytes and hepatocytes. Margaret Hoffman-Terry, M.D., reports.
In 4th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention, from The Body PRO - Testosterone Levels, Fat Free Mass, Increases Differ According to HIV Drugs Taken (June 4, 2007)
From aidsmap.com - Chewing the Fat Contributes to Dyslipidemia in HIV-Infected Individuals, Study Finds (March 9, 2007)
In aidsmap.com - Metabolic Complications: A CROI Round-Up (February 28, 2007)
Includes an analysis of research examining lopinavir/ritonavir vs. efavirenz, the use of growth hormone releasing factor to treat fat gain, the link between cardiovascular disease and HIV treatment, the use of ezetimibe (a choleserol-reducing agent) and the latest on bone health in HIV-infected patients.
In Exclusive Coverage of the 14th Conference on Retroviruses and Opportunistic Infections, from The Body PRO - Metabolic Syndrome as Common in HIV-Negative as in HIV-Positive Individuals (February 15, 2007)
From aidsmap.com
- Lipid Abnormalities in HIV/Hepatitis C Virus-Coinfected Patients (November 2006)
In HIV Medicine - Metabolic Complications of HIV Therapy (September 2006)
To read PDF, click here.
In IAPAC Monthly, from International Association of Physicians in AIDS Care - Initiation of HAART May Increase Free Testosterone Levels and Fat-Free Mass (August 17, 2006)
In XVI International AIDS Conference - Metabolic Complications at the XVI International AIDS Conference: Part 1 -- An Overview of New Data (August 17, 2006)
In XVI International AIDS Conference - Metabolic Complications at the XVI International AIDS Conference: Part 2 -- Lipids (August 17, 2006)
In XVI International AIDS Conference - Body Fat Changes in People With HIV (August 14, 2006)
An interview with Todd Brown, M.D., Johns Hopkins School of Medicine.
In The XVI International AIDS Conference - Interventions for Fat Changes: New Research on Glitazones, Metformin and Testosterone (February 8, 2006)
In The 13th Conference on Retroviruses and Opportunistic Infections, from The Body PRO - PI-Based Therapy Does Not Increase Glucose Intolerance, Gestational Diabetes in Pregnant, HIV-Infected Women (February 6, 2006)
In The 13th Conference on Retroviruses and Opportunistic Infections - HIV JournalView: Metabolic Complications and HAART: Some New Answers and Many More Questions (January 2006)
Part of David Wohl, M.D.'s review of the top 10 HIV research reports of 2005.
In HIV JournalView, from The Body PRO
- HIV JournalView: Study Ties Insulin Resistance to NRTIs, Not PIs (September 2005)
d4T and 3TC are associated with insulin resistance and high insulin levels; indinavir is associated only with elevated insulin levels; and no link to insulin abnormalities is found for AZT or ddI.
From The Body PRO - Moderate Weight Loss Increasingly Common for HIVers on HAART (September 1, 2005)
Wasting syndrome may be on the decline, but moderate weight loss -- of 5% or more -- has increased steadily since 1995, and appears unrelated to lipodystrophy.
From aidsmap.com - HIV JournalView: Exporting Lipodystrophy: d4T Usage in Developing World (July/August 2005)
From The Body PRO - Metabolic Syndrome Among HIV-Infected Patients: Prevalence, Characteristics, and Related Factors (January 2005)
Abstract of a study published in Diabetes Care.
From International Association of Physicians in AIDS Care
- CROI 2004 Select Poster Abstracts: Metabolic Complications (January 2004)
From International Association of Physicians in AIDS Care