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BROWSE TOPICS IN CLINICAL MANAGEMENT:
Antiretroviral Therapy- Complications of HIV/HAART
- Research & Development
- Clinical Trials
- Quality of Life & Patient Care
Antiretroviral Therapy
Specific HIV Medication Interactions
General
- ARV Alert (Regularly Updated)
Periodic updates on newly announced interactions involving HIV medications; each update features a brief synopsis of the interaction, as well as a chart outlining key information.
From HIV InSite - Important Updates to the Reyataz (Atazanvir) Label (August 21, 2008)
From U.S. Food and Drug Administration - Prescribing Information for Atazanavir (Reyataz) (PDF) (December 2007)
From Bristol-Myers Squibb Company - Acid-Reducing Agents Reduce Atazanavir Drug Levels but Not Lopinavir/Ritonavir Levels (February 7, 2006)
In The 13th Conference on Retroviruses and Opportunistic Infections - French Study Questions Interaction Between Atazanavir and Antacids (October 24, 2005)
From aidsmap.com - ddI + Ribavirin May Cause Mitochondrial Toxicity (September 1, 2005)
In Journal of Acquired Immune Deficiency Syndromes - Efavirenz Reduces Plasma Levels of Popular Statins (July/August 2005)
From The Body PRO - A Review of Interactions Between Natural Health Products and HIV Medications (April 2005)
A brief summary of a report in the International Journal of STD & AIDS.
From The Body PRO - Notice of Important New Drug Interactions With Norvir, Kaletra (March 30, 2005)
New interactions noted with fluticasone (a component of Flonase nasal spray) and trazodone (Desyrel, an antidepressant).
From U.S. Food and Drug Administration - Drug Interaction Warning: Saquinavir/Ritonavir and Rifampin (Rifampicin, Rifadin, Rimactane, Rofact) (February 8, 2005)
To read PDF, click here
From U.S. Food and Drug Administration - Don't Combine Fosamprenavir and Lopinavir/Ritonavir (February/March 2005)
From The Body PRO - Do Not Combine Reyataz and Prilosec: News Summary (December 31, 2004)
In AIDS Treatment News, from AIDS Treatment News - Atazanavir, With or Without Ritonavir, Should Not Be Coadministered With Proton Pump Inhibitors (December 20, 2004)
From U.S. Food and Drug Administration - Warning Against Using Erythromycin (Even Orally) While Using Protease Inhibitors or Certain Other Drugs (October 26, 2004)
A study finds an increased risk of sudden death from cardiac causes.
In AIDS Treatment News, from AIDS Treatment News - ddI + Tenofovir Combination Linked to Higher Pancreatitis Risk (October 2004)
Quick recap of a report in The Lancet.
In HIV Treatment ALERTS!, from The Center for AIDS - Interaction Reported Between Grapefruit Juice and Statins (October 2004)
This interaction may also worsen other interactions between statins and HIV medications.
In HIV Treatment ALERTS!, from The Center for AIDS - Genetics Influence Response to HAART and Incidence of Pancreatitis, Studies Show (August 3, 2004)
From aidsmap.com - Changes to Labeling for Desyrel (Trazodone Hydrochloride) Tablets (PDF) (May 2004)
A "Dear Healthcare Professional" letter on potential interactions between this antidepressant and CYP3A4 inhibitors such as indinavir and ritonavir.
From U.S. Food and Drug Administration - Atazanavir/Tenofovir Combo Should Be Boosted With Ritonavir (August 8, 2003)
From U.S. Food and Drug Administration - HIV-Positive Man Dies of Kidney Failure and Lactic Acidosis Due to Tenofovir/ddI Interaction (April 8, 2003)
From aidsmap.com - Tenofovir DF and Didanosine EC: Investigation of Pharmacokinetic Drug-Drug and Drug-Food Interactions (November 21, 2002)
In The 6th International Congress on Drug Therapy in HIV Infection, from The Body PRO - Intracellular Metabolism of AZT Leads to the Production of Significant Levels of d4T Triphosphate in HIV Infected Patients (November 19, 2002)
In The 6th International Congress on Drug Therapy in HIV Infection, from The Body PRO - New Safety Information -- Viread Co-Administration With Videx (September 30, 2002)
From U.S. Food and Drug Administration - Viread-Videx EC Drug Interactions -- What's a Person to Do? (Fall 2002)
To read PDF, click here
In STEP Perspective, from Seattle Treatment Education Project - New Safety Information for Videx (Didanosine, ddI) Used With Ribavirin (September 25, 2002)
From U.S. Food and Drug Administration - Drug Interactions Need More Attention (January 25, 2002)
To read PDF, click here
In AIDS Treatment News, from AIDS Treatment News - Caution With Nelfinavir and Some Lipid-Lowering Drugs (November 21, 2001)
From Canadian AIDS Treatment Information Exchange - Bizarre Side Effects From an Interaction Between Nevirapine and Clarithromycin (August 17, 2001)
From Canadian AIDS Treatment Information Exchange - Women and Pharmacology (March 2001)
To read PDF, click here
In Project Inform Perspective, from Project Inform - Drug Interactions of Protease Inhibitors and Psychiatric Medications (January 2001)
In Survival News, from AIDS Survival Project - Will Pharmacogenomic Discoveries Improve HIV Therapeutics? by David W. Haas, M.D. (June 2005)
PowerPoint presentation from the 8th Annual Clinical Conference for Ryan White CARE Act.
From International AIDS Society-USA - CROI 2004 Select Poster Abstracts: Pharmacokinetics (April 2004)
From International Association of Physicians in AIDS Care - Indinavir Concentrations Plummet When Coadministered With Rifampicin (February 2004)
From International Association of Physicians in AIDS Care
St. John's Wort
- St. John's Wort Found to Lower Nevirapine Levels (March 2, 2001)
From Canadian AIDS Treatment Information Exchange
Viagra
- Viagra and Grapefruit Juice -- Not a Good Mix (February 12, 2002)
From Canadian AIDS Treatment Information Exchange
Cholesterol-Lowering Medications (Statins)
- Drug/Drug Interaction Between Lopinavir/Ritonavir and Rosuvastatin in Healthy Volunteers. (February 14, 2008)
In Journal of Acquired Immune Deficiency Syndromes - Efavirenz Reduces Plasma Levels of Popular Statins (July/August 2005)
From The Body PRO - Interaction Reported Between Grapefruit Juice and Statins (October 2004)
This interaction may also worsen other interactions between statins and HIV medications.
In HIV Treatment ALERTS!, from The Center for AIDS
Birth Control Pills
- Antiretroviral Medications and Oral Contraceptive Agents (2007)
From Clinical Manual for Management of the HIV-Infected Adult.
In Canadian Medical Association Journal, from AIDS Education & Training Centers National Resource Center - High Dose of Vitamin C Significantly Reduces Indinavir Levels in Pilot Study (September 16, 2003)
In The 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy, from The Body PRO
Vitamins
- Vitamin A (Beta Carotene and Retinoids) and HIV Drug Interactions (January 2003)
Research from the 2002 International AIDS Conference.
In Project Inform Perspective, from Project Inform - Vitamin E, Vitamin A and Anti-HIV Therapies (January 2003)
Research from the 2002 International AIDS Conference.
In Project Inform Perspective, from Project Inform
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