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ShareHIV Drug-Drug Interactions
Overview
- Labeling for Protease Inhibitors Updated With New Info on Drug-Drug Interactions (April 27, 2010)
From U.S. Food and Drug Administration - Interactions Between NNRTIs, Maraviroc, Raltegravir, and PIs (PDF) (December 1, 2009)
An excerpt from the official U.S. HIV treatment guidelines for adults and adolescents. For the full guidelines, click here (PDF).
From AIDSinfo - Interactions Among Protease Inhibitors (PDF) (December 1, 2009)
An excerpt from the official U.S. HIV treatment guidelines for adults and adolescents. For the full guidelines, click here (PDF).
From AIDSinfo - Drug Interactions Between NNRTIs and Other Drugs (PDF) (December 1, 2009)
An excerpt from the official U.S. HIV treatment guidelines for adults and adolescents. For the full guidelines, click here (PDF).
From AIDSinfo - Drug Interactions Between NRTIs and Other Drugs (Including Antiretroviral Agents) (PDF) (December 1, 2009)
An excerpt from the official U.S. HIV treatment guidelines for adults and adolescents. For the full guidelines, click here (PDF).
From AIDSinfo - Drug Interactions Between Protease Inhibitors (PIs) and Other Drugs (PDF) (December 1, 2009)
An excerpt from the official U.S. HIV treatment guidelines for adults and adolescents. For the full guidelines, click here (PDF).
From AIDSinfo - Drugs That Should Not Be Used With PI, NNRTI , or CCR5 Antagonist Antiretrovirals (PDF) (December 1, 2009)
An excerpt from the official U.S. HIV treatment guidelines for adults and adolescents. For the full guidelines, click here (PDF).
From AIDSinfo - Drug Interactions Between CCR5 Antagonists, Integrase Inhibitors and Other Drugs (PDF) (December 1, 2009)
An excerpt from the official U.S. HIV treatment guidelines for adults and adolescents. For the full guidelines, click here (PDF).
From AIDSinfo - Dosage Adjustments for ARV-ARV Drug Interactions (Adult Dosing) (July 2006)
[Archived Article]
From AIDS Education & Training Centers National Resource Center - Antiretroviral Medications and Oral Contraceptive Agents (2006)
[Archived Article]
A chapter from Clinical Manual for Management of the HIV-Infected Adult.
From AIDS Education & Training Centers National Resource Center - Drug Interactions and Anti-HIV Therapy (Summer 2005)
[Archived Article]
To read PDF, click here.
In Bulletin of Experimental Treatments for AIDS, from San Francisco AIDS Foundation - A Review of Interactions Between Natural Health Products and HIV Medications (April 2005)
A brief summary of a report in the International Journal of STD & AIDS.
From The Body PRO - Psychiatric and HIV Medication Interactions (January 2005)
[Archived Article]
A chart outlining known interactions between psychiatric medications and NRTIs, NNRTIs and protease inhibitors.
To read PDF, click here.
In Infectious Diseases in Corrections Report, from Brown Medical School - Drug Interactions Fact Sheet (August 2004)
[Archived Article]
An exhaustive list of drug interactions.
To read PDF, click here.
From Project Inform - Case Study: Drug-Drug Interactions Associated With the Use of Antiretroviral Therapy (March 2004)
In HEPP Report, from Brown Medical School - Clinically Significant Drug Interactions Associated With Highly Active Antiretroviral Therapy (January 2004)
[Archived Article]
To read PDF, click here.
In HEPP Report, from Brown Medical School - Risky Cocktails (April 2003)
[Archived Article]
A chart of interactions between alcohol/recreational drugs and HIV antiretrovirals.
In Survival News, from AIDS Survival Project - The Effects of Club Drugs on HAART (December 2002)
[Archived Article]
To read PDF, click here.
In IAPAC Monthly, from International Association of Physicians in AIDS Care - Methadone and HIV Medications: Drug Interactions (Winter 2002/2003)
[Archived Article]
To read PDF, click here.
In STEP Perspective, from Seattle Treatment Education Project - Pharmacology and Drug Interactions: A Progress Report (September 2002)
[Archived Article]
A report from the International AIDS Conference.
In Hopkins HIV Report - Drug Interactions: Ritonavir as PI Booster (July 2001)
[Archived Article]
From Project Inform - Drug-Drug Interactions With HIV-Related Medications (2006)
A chapter from Clinical Manual for Management of the HIV-Infected Adult.
From AIDS Education & Training Centers National Resource Center - Recreational Drugs and Antiretroviral Therapy (2006)
A chapter from Clinical Manual for Management of the HIV-Infected Adult.
From AIDS Education & Training Centers National Resource Center
Drug Interaction Research
- Drug Monitoring and Pharmacology: More Mixes Nixed By Concentration Preoccupations (August 2004)
[Archived Article]
Highlights from a CROI 2004 post-conference workshop on drug-drug interactions.
In TAGline, from Treatment Action Group - Tipranavir Reduces Concentrations of Other Protease Inhibitors (July 14, 2004)
[Archived Article]
In The XV International AIDS Conference, from The Body PRO - Tenofovir and Abacavir Do Not Interact in Patients on Triple-Nucleoside Regimens (July 13, 2004)
[Archived Article]
In The XV International AIDS Conference, from The Body PRO - Making Right Turns in the HIV Pharmacology Maze: 5th International Workshop on Clinical Pharmacology of HIV Therapy (July 2004)
[Archived Article]
Highlighted research on host factor relevance, new antiretrovirals and drug-drug interactions.
To read PDF, click here.
In IAPAC Monthly, from International Association of Physicians in AIDS Care - Efavirenz May Reduce Blood Levels of Cholesterol Drugs (March/April 2004)
[Archived Article]
A study presented at CROI 2004 suggests an interaction between efavirenz and simvastatin (Zocor) or atorvastatin (Lipitor).
In Positively Aware, from Test Positive Aware Network - Dosing Agenerase + Kaletra -- Trying to Juggle, Walk and Chew Gum All at the Same Time (March/April 2004)
[Archived Article]
A study presented at CROI 2004 bolsters support for the use of therapeutic drug monitoring to customize dosing.
In Positively Aware, from Test Positive Aware Network - Pharmacokinetic Interactions of 908 (September 16, 2003)
[Archived Article]
In The 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy, from The Body PRO - A Look at Tenofovir Drug-Drug Interactions (September 16, 2003)
[Archived Article]
In The 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy, from The Body PRO - No PK Interaction Seen Between FTC and AZT or Tenofovir (September 16, 2003)
[Archived Article]
In The 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy, from The Body PRO - No Interactions Between Tipranavir/Ritonavir and Efavirenz, Tenofovir and AZT (July 14, 2003)
[Archived Article]
In The 2nd International AIDS Society Conference on HIV Pathogenesis and Treatment, from The Body PRO - HIV-Positive Man Dies of Kidney Failure and Lactic Acidosis Due to Tenofovir/ddI Interaction (April 8, 2003)
[Archived Article]
From aidsmap.com - Pharmacokinetic Parameters of Atazanavir/Ritonavir When Combined to Tenofovir in HIV Infected Patients With Multiple Treatment Failures: A Substudy of Puzzle2-ANRS 107 Trial (February 12, 2003)
[Archived Article]
In The 10th Conference on Retroviruses and Opportunistic Infections, from The Body PRO - Lack of Interaction Between Stavudine Extended-Release Formulation and Tenofovir Disoproxil Fumarate (February 12, 2003)
[Archived Article]
In The 10th Conference on Retroviruses and Opportunistic Infections, from The Body PRO - Didanosine and Tenofovir DF Drug-Drug Interaction: Assessment of Didanosine Dose Reduction (February 12, 2003)
[Archived Article]
In The 10th Conference on Retroviruses and Opportunistic Infections, from The Body PRO - New Questions About an Old Combination -- ddI + d4T (January 2003)
[Archived Article]
To read PDF, click here.
In Project Inform Perspective, from Project Inform - Tenofovir DF and Didanosine EC: Investigation of Pharmacokinetic Drug-Drug and Drug-Food Interactions (July 11, 2002)
[Archived Article]
In The XIV International AIDS Conference, from The Body PRO - Polypharmacy Problems: Drug Interactions in the Multi-Drug Therapy of HIV Infection (February 6, 2002)
[Archived Article]
In The PRN Notebook - Ingrown Toenails Still a Possible Side Effect (November 2001)
[Archived Article]
Indinavir-ritonavir interaction is possible culprit.
In HIV Treatment ALERTS!, from The Center for AIDS - Drug Interaction: Ritonavir and Fluticasone (November 2001)
[Archived Article]
Possible link found to Cushing's Syndrome.
In HIV Treatment ALERTS!, from The Center for AIDS - Lack of Clinically Relevant Drug-Drug Interactions Between Tenofovir DF and Efavirenz, Indinavir, Lamivudine and Lopinavir/Ritonavir in Healthy Subjects (October 29, 2001)
[Archived Article]
In 8th European Conference on Clinical Aspects and Treatment of HIV-Infection, from The Body PRO - Minor Interaction Between Efavirenz and Saquinavir When Combined With Small Doses of Ritonavir in a QD Regimen (October 28, 2001)
[Archived Article]
In 8th European Conference on Clinical Aspects and Treatment of HIV-Infection, from The Body PRO
Drug-Drug Interaction Tools
- Database of Antiretroviral Drug Interactions (Regularly Updated)
Search through this comprehensive, fully-referenced database of interactions involving at least one antiretroviral drug.
From HIV InSite - Drug Interaction Checker (Regularly Updated)
Free registration required in order to view.
From Medscape - HIV-druginteractions.org: Online Resource on Drug Interactions (Regularly Updated)
Maintained by the University of Liverpool and geared toward healthcare professionals; features interactive charts for assessing the risks of interaction between protease inhibitors, NNRTIs and other drugs.
From University of Liverpool
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