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BROWSE TOPICS IN CLINICAL MANAGEMENT:
Antiretroviral Therapy- Complications of HIV/HAART
- Research & Development
- Clinical Trials
- Quality of Life & Patient Care
Antiretroviral Therapy
Cardiovascular Disease & HIV: Research & News
See also: Cardiovascular Complications & HIV
- Literature Citations for Diagnosis of Cardiovascular Disease and HIV (Regularly Updated)
From U.S. National Institutes of Health - Literature Citations for Treatment of Cardiovascular Disease and HIV (Regularly Updated)
From U.S. National Institutes of Health - Surprising Rate of Serious Heart Condition Found in Those on HAART (December 2008)
To read PDF, click here
In Project Inform Perspective, from Project Inform - Markers of Inflammation and Blood-Clotting Tied to Hazards of Intermittent HIV Treatment (October 21, 2008)
From National Institute of Allergy and Infectious Diseases - Low CD4 Cell Count, But Not HIV Treatment, Increases Risk of Hardening of the Arteries (August 19, 2008)
From aidsmap.com - New SMART Study Analysis Appears to Confirm Link Between Abacavir and Myocardial Infarction Risk (August 1, 2008)
An interview with Jens Lundgren, M.D.
In The XVII International AIDS Conference, from The Body PRO - Insulin Resistance May Predict Risk of Cardiovascular Disease in HIV (May 8, 2008)
From aidsmap.com - Anti-Inflammatory Drug Could Reduce Heart Disease Risk in Patients With HIV (March 14, 2008)
From aidsmap.com - Abacavir, Didanosine Associated With Higher Heart Attack Risk, D:A:D Study Finds (February 5, 2008)
An interview with Jens Lundgren, M.D.
In 15th Conference on Retroviruses and Opportunistic Infections, from The Body PRO - Increased Risk of Myocardial Infarction Associated With Abacavir and ddI (February 4, 2008)
From HIV i-Base - Position Statement by the D:A:D Steering Committee (February 4, 2008)
A discussion of the significance of a study examining the association between use of abacavir, didanosine and lamivudine and the risk of myocardial infarction.
To read PDF, click here
From D:A:D Steering Committee - Short-Term Ritonavir Exposure Impacts HDL, CD36 and Triglyceride Levels in Healthy Volunteers (February 4, 2008)
Marta Boffito, M.D., Ph.D., discusses her study, which examines the possible role of ritonavir in increasing cardiovascular risk.
From The Body PRO - Study Finds Heart Trouble With Ziagen and Videx (February 4, 2008)
From Project Inform - HIV-Positive Patients Have High Prevalence of Asymptomatic Heart Disease in US Study, But Traditional Risk Factors and Cocaine Use Main Causes (January 23, 2008)
From aidsmap.com - Spanish Find Low Prevalence of Peripheral Arterial Disease in HIV-Positive Patients With Heart Disease Risks (January 9, 2008)
From aidsmap.com - IAS: Cardiovascular Disease and Diabetes Increasing as Causes of Death for People With HIV in Brazil (July 25, 2007)
From aidsmap.com - Insight Into the Burden of Coronary Artery Disease in HIV-Infected Patients (July 24, 2007)
This is the first moderately sized study to examine at a histological level the lesions associated with the increased risk of myocardial infarction among HIV-infected individuals that has been reported in multiple case series and cohort studies. Margaret Hoffman-Terry, M.D., reports.
In 4th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention, from The Body PRO - Efavirenz to Nevirapine Switch in HIV-1-Infected Patients with Dyslipidemia: A Randomized, Controlled Study (June 6, 2007)
Small French study finds that switching NNRTIs may somewhat reduce abnormally high LDL cholesterol levels.
In Clinical Infectious Diseases - Antiretroviral Therapy Carries Same Risk of Ischaemic Heart Disease as 1-4 Cigarettes a Day, Danish Study Shows (May 23, 2007)
From aidsmap.com - Heart Attack Risk Seen in Drug for Diabetes (May 22, 2007)
In The New York Times - No Imminent Epidemic of Heart Disease Among HIVers on Meds, Expert Says (May 1, 2007)
From aidsmap.com - HIV-Infected Patients -- Particularly Women -- More Likely to Have AMIs, New Study Finds (April 12, 2007)
In Journal of Clinical Endocrinology & Metabolism - Reduction in Triglyceride Level With N-3 Polyunsaturated Fatty Acids in HIV-Infected Patients Taking Potent Antiretroviral Therapy: A Randomized Prospective Study (March 1, 2007)
In Journal of Acquired Immune Deficiency Syndromes - Metabolic Complications: A CROI Round-Up (February 28, 2007)
Includes an analysis of research examining lopinavir/ritonavir vs. efavirenz, the use of growth hormone releasing factor to treat fat gain, the link between cardiovascular disease and HIV treatment, the use of ezetimibe (a choleserol-reducing agent) and the latest on bone health in HIV-infected patients.
In Exclusive Coverage of the 14th Conference on Retroviruses and Opportunistic Infections, from The Body PRO - Cardiovascular Disease Risk Higher Among HIV/HCV-Coinfected Patients (January 11, 2007)
In AIDS - HIV or Antiretrovirals? New Data May Shift Debate Over Causes of Cardiovascular Complications (October 31, 2006)
In PLoS Biology - Cardiovascular Risk and Antiretroviral Therapy: New Research on Epidemiology, Pathogenesis and Treatment (February 8, 2006)
In The 13th Conference on Retroviruses and Opportunistic Infections - HIV JournalView: A Supersized Epidemic: The Twin Problems of Obesity and HIV (January 2006)
Part of David Wohl, M.D.'s review of the top 10 HIV research reports of 2005.
In HIV JournalView, from The Body PRO - HIV JournalView: Dosing Adjustment Likely Needed for Statins Taken With NNRTIs (January 2006)
Part of David Wohl, M.D.'s review of the top 10 HIV research reports of 2005.
In HIV JournalView, from The Body PRO - HIV JournalView: Obesity Growing Increasingly Common Among HIV-Infected Patients (September 2005)
A new report cautions that the major body shape issue confronting HIV-infected U.S. patients -- particularly African Americans -- is garden-variety obesity.
From The Body PRO - HIV JournalView: Carotid Intima-Media Thickness Not Associated With Protease Inhibitor Use (July/August 2005)
From The Body PRO - HIV JournalView: HAART Associated With Long-Term Risk of Systolic Hypertension (July/August 2005)
From The Body PRO - HIV JournalView: Managing Dyslipidemias: Is It Better to Fight or Switch? (July/August 2005)
From The Body PRO - Efavirenz Reduces Plasma Levels of Popular Statins (July/August 2005)
From The Body PRO - HIV JournalView: Changes in Atherosclerosis Progression in HIV: Evolution of Carotid Intima-Media Thickness (May/June 2005)
From The Body PRO - Body Fat Changes Associated With Greater Cardio Disease Risk in Women With HIV (May 1, 2005)
In Journal of Acquired Immune Deficiency Syndromes - A Review Worth Reviewing: Metabolic Complications of HIV and HIV Therapies (February/March 2005)
A note on an overview in the New England Journal of Medicine written by two of the foremost authorities on this issue.
From The Body PRO - Cardiovascular Risk and Body-Fat Abnormalities in HIV-Infected Adults (January 6, 2005)
In New England Journal of Medicine - Warning Against Using Erythromycin (Even Orally) While Using Protease Inhibitors or Certain Other Drugs (October 26, 2004)
A study finds an increased risk of sudden death from cardiac causes.
In AIDS Treatment News, from AIDS Treatment News - Breathing Problems: Pulmonary Arterial Hypertension More Common, Treatment More Complicated in HIV-Positive People (October 2004)
In HIV Treatment ALERTS!, from The Center for AIDS - Extended-Release Niacin May Reduce Dyslipidemia, But Dangerous for Diabetic Patients (October 2004)
Quick recap of a study in the journal Clinical Infectious Diseases.
In HIV Treatment ALERTS!, from The Center for AIDS - HAART Users Warned About Combination of Two Lipid-Lowering Drugs (September 17, 2004)
When fibrates and glitazones are prescribed together in people on HAART, they appear to significantly raise triglycerides and dramatically lower good cholesterol.
From Canadian AIDS Treatment Information Exchange - Stroke Risk, Odds of Bypass Surgery Increase for Every Year on HAART (August 27, 2004)
New results from the landmark D:A:D study supplement last year's findings that heart attack risk increases 26% for each year on HAART.
From aidsmap.com - Protease Inhibitors Appear More Likely to Cause Atherosclerosis Than NNRTIs (July 15, 2004)
In The XV International AIDS Conference, from The Body PRO - HDL Benefit Is Maintained With Extension of Nevirapine and Efavirenz Treatment in 2NN Study (July 14, 2004)
In The XV International AIDS Conference, from The Body PRO - Hypertriglyceridemic Patients on HAART Have Increased Risk of Cardiovascular Disease (July 14, 2004)
In The XV International AIDS Conference, from The Body PRO - Increased Cardiovascular Risk Indices in HIV-Infected Women (July 14, 2004)
In The XV International AIDS Conference, from The Body PRO - HIV and Cardiovascular Disease: Responding to the Risk (April 2004)
An in-depth review of research on the increasingly complicated topic of cardiovascular disease in people with HIV.
In The PRN Notebook - Atherosclerosis Risk Increased With HIV; Treatment Effects Unclear (March 26, 2004)
A major study finds that HIV infection itself is associated with increased risk of heart disease.
In AIDS Treatment News, from AIDS Treatment News - HIV "Raises Heart Disease Risk" (March 16, 2004)
Researchers find higher rates of atherosclerosis among people with HIV, particularly those who smoke or have high blood pressure.
From BBC News - Diabetes Drug and Exercise Help Reduce Heart Disease Risk and Improve Body Shape in HAART Patients (March 12, 2004)
From aidsmap.com - Cardiovascular Disease Risk Factors and Antiretroviral Therapy in an HIV-Positive UK Population (March 2004)
In HIV Medicine - Complications of Antiretroviral Therapies and HIV (March 2004)
An examination of diabetes, kidney disease, bone problems and hypertension research from the February Retrovirus conference.
In Hopkins HIV Report - Efavirenz May Reduce Blood Levels of Cholesterol Drugs (March/April 2004)
A study presented at CROI 2004 suggests an interaction between efavirenz and simvastatin (Zocor) or atorvastatin (Lipitor).
In Positively Aware, from Test Positive Aware Network - A Review of the Cardiovascular Complications of HIV/HAART (February 11, 2004)
In The 11th Conference on Retroviruses and Opportunistic Infections, from The Body PRO - Color Doppler Ultrasonographic Comparison of PI vs. NNRTI Regimens (February 10, 2004)
In The 11th Conference on Retroviruses and Opportunistic Infections, from The Body PRO - HIV-Infected Patients Have Multiple Risk Factors for Cardiovascular Disease (February 9, 2004)
In The 11th Conference on Retroviruses and Opportunistic Infections, from The Body PRO - HIV May Trigger Events That Lead to Severe Heart Attack (January 2004)
In American Heart Journal - New Guidelines for Management of Dyslipidemia From IDSA and the ACTG (January 2004)
A summary of the updated guidelines.
In Hopkins HIV Report - Elevated Blood Pressure in HIV-Infected Individuals Receiving Highly Active Antiretroviral Therapy (November/December 2003)
In HIV Clinical Trials - Endothelial Function in HIV-Infected Patients Receiving Protease Inhibitor Therapy: Does Immune Competence Affect Cardiovascular Risk? (November 2003)
Abstract of a study in the Quarterly Journal of Medicine.
In IAPAC Monthly, from International Association of Physicians in AIDS Care - Association Between Protease Inhibitor Use and Increased Cardiovascular Risk in Patients Infected With Human Immunodeficiency Virus: A Systematic Review (September 12, 2003)
In Clinical Infectious Diseases - Major Risk Factors as Antecedents of Fatal and Nonfatal Coronary Heart Disease Events (August 20, 2003)
Coronary heart disease almost never happens to people with no risk factors, according to this study of HIV-negative patients.
In Journal of the American Medical Association - HIV Patients Have More Heart Disease Risk Factors (July 25, 2003)
In CDC HIV/Hepatitis/STD/TB Prevention News Update, from U.S. Centers for Disease Control and Prevention - Evidence Mounts Regarding Antiretroviral Therapy-Associated Cardiovascular Complications (July 14, 2003)
In The 2nd International AIDS Society Conference on HIV Pathogenesis and Treatment, from The Body PRO - It Is Reasonable to Modify Therapy in Patients With Multiple Cardiovascular Risk Factors (July 14, 2003)
In The 2nd International AIDS Society Conference on HIV Pathogenesis and Treatment, from The Body PRO - Metabolic and Virologic Responses to Different Regimens Vary by Gender and Race (July 14, 2003)
In The 2nd International AIDS Society Conference on HIV Pathogenesis and Treatment, from The Body PRO - Switch to Nevirapine From Protease Inhibitor Lowers Triglycerides and Maintains Viral Load Suppression (July 14, 2003)
In The 2nd International AIDS Society Conference on HIV Pathogenesis and Treatment, from The Body PRO - Trizivir Causes Lowest Triglycerides Rise in Comparison With Combivir + Nelfinavir or d4T (July 14, 2003)
In The 2nd International AIDS Society Conference on HIV Pathogenesis and Treatment, from The Body PRO - HIV and Cardiovascular Medicine (July 2003)
In Heart - Exercise Linked to Lower Triglyceride Levels on HAART (June 18, 2003)
Vitamin E intake is also associated with lower blood pressure and body fat percentage.
From aidsmap.com - Early HAART Extends Life, Costs Less, Study Says -- Despite Cardiovascular Risks (June 11, 2003)
In CDC HIV/Hepatitis/STD/TB Prevention News Update, from U.S. Centers for Disease Control and Prevention - Highly Active Antiretroviral Therapy Does Not Significantly Raise Cholesterol Levels, Study Says (June 11, 2003)
Contrary to what many people theorized, HAART actually appears to bring cholesterol levels back to what they were before a person was infected with HIV.
In Kaiser Daily HIV/AIDS Report, from Henry J. Kaiser Family Foundation - European Agency Backs Cardiovascular Safety Studies on HIV Drugs (May 16, 2003)
In CDC HIV/Hepatitis/STD/TB Prevention News Update, from U.S. Centers for Disease Control and Prevention - Link Between HAART, Cardiovascular Events Questioned (April 22, 2003)
In CDC HIV/Hepatitis/STD/TB Prevention News Update, from U.S. Centers for Disease Control and Prevention - Older PIs Linked to Early Coronary Artery Disease (April 7, 2003)
In CDC HIV/Hepatitis/STD/TB Prevention News Update, from U.S. Centers for Disease Control and Prevention - HAART to Heart Talk (April 2003)
Continued controversy over HAART-related vascular disease risk.
In GMHC Treatment Issues, from Gay Men's Health Crisis - Hearts, Flowers, HAART (April 2003)
An overview of developing antietrovirals noted at CROI 2003.
In IAPAC Monthly, from International Association of Physicians in AIDS Care - Prediction of Coronary Heart Disease Risk in HIV-Infected Patients With Fat Redistribution (April 1, 2003)
In Clinical Infectious Diseases - Retroviruses Conference Clinical News: Interview With Cal Cohen, M.D. (March 14, 2003)
Dr. Cohen discusses starting antiretroviral therapy (tenofovir vs. d4T, efavirenz vs. nevirapine), new protease inhibitor information (atazanavir and fos-amprenavir, a.k.a. "908") and antiretroviral-associated cardiovascular problems (the D:A:D study).
In AIDS Treatment News, from AIDS Treatment News - Heart Disease and HAART: Conflicting Studies (Spring 2003)
In STEP Perspective, from Seattle Treatment Education Project - Cardio Disease Less Frequent in HAART Era, Study Finds (February 21, 2003)
In CDC HIV/Hepatitis/STD/TB Prevention News Update, from U.S. Centers for Disease Control and Prevention - Cardiovascular and Cerebrovascular Events in Patients Treated for Human Immunodeficiency Virus Infection (February 20, 2003)
In New England Journal of Medicine - Carotid Intima-Media Thickness in HIV-Infected and Uninfected Adults: ACTG 5078 (February 13, 2003)
In The 10th Conference on Retroviruses and Opportunistic Infections, from The Body PRO - Exposure to HAART Is Associated With an Increased Risk of Myocardial Infarction: The D:A:D Study (February 13, 2003)
In The 10th Conference on Retroviruses and Opportunistic Infections, from The Body PRO - Can You Fight Heart Disease With Fish? (January 21, 2003)
From Canadian AIDS Treatment Information Exchange - Cost-Effectiveness Implications of the Timing of Antiretroviral Therapy in HIV-Infected Adults (November 25, 2002)
A study asserts that, generally speaking, the risks of lipodystrophy and heart disease are outweighed by the benefits of early HIV treatment.
In Archives of Internal Medicine - Heart-Disease Risk and C-Reactive Protein (November 22, 2002)
In AIDS Treatment News, from AIDS Treatment News - Incidence of Cardiac Abnormalities in Children With HIV Infection (October 2002)
An abstract from Journal of Pediatrics.
In IAPAC Monthly, from International Association of Physicians in AIDS Care - A Prospective, Multicenter, Randomized Trial Comparing the Efficacy and Safety of Fenofibrate Versus Pravastatin in HIV-Infected Subjects With Lipid Abnormalities (ACTG 5087) (July 11, 2002)
In The XIV International AIDS Conference, from The Body PRO - Perspective of HIV-Associated Coronary Heart Disease (July 10, 2002)
In The XIV International AIDS Conference, from The Body PRO - Simplification of Protease Inhibitor-Based Highly Active Antiretroviral Regimens With Abacavir Improves Hyperlipidemia and Maintains Viral Suppression in HIV-1-Infected Adults (ESS40003) (July 10, 2002)
In The XIV International AIDS Conference, from The Body PRO - 9th Retrovirus Conference Coverage: Cardiovascular Complications of Therapy (Spring 2002)
In STEP Perspective, from Seattle Treatment Education Project - Distinguishable Lipid Profiles Between PI and NNRTI Therapy May Carry Different Risk of Cardiovascular Disease (CVD) (February 25, 2002)
In The 9th Conference on Retroviruses and Opportunistic Infections, from The Body PRO - Risks for Cardiovascular Disease Associated With Antiretroviral Therapy (December 18, 2001)
In 41st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2001), from The Body PRO - Pulmonary Hypertension Associated With HIV Infection (November 2001)
In Body Positive, from Body Positive - Cardiovascular Risk Factors in HIV Patients: Association With Antiretroviral Therapy (The DAD Study) (October 30, 2001)
In 8th European Conference on Clinical Aspects and Treatment of HIV-Infection, from The Body PRO - Combined Antiretroviral Therapy Causes Cardiomyopathy (July 10, 2001)
In The 1st International AIDS Society Conference on HIV Pathogenesis and Treatment, from The Body PRO - Low Prevalence of Cardiac Abnormalities in an HIV-Seropositive Population on Antiretroviral Combination Therapy (July 1, 2001)
In Journal of Acquired Immune Deficiency Syndromes - Increases in Cardiovascular Disease Risk (March 22, 2001)
Report from the 8th Conference on Retroviruses and Opportunistic Infections.
In STEP Ezine, from Seattle Treatment Education Project - ACTG 5056: Metabolic Status and Cardiovascular Disease Risk for a Cohort of HIV-1-Infected Persons Durably Suppressed on an Indinavir-Containing Regimen (ACTG 372A) (February 7, 2001)
In The 8th Conference on Retroviruses and Opportunistic Infections, from The Body PRO - Do Protease Inhibitors Increase the Risk for Coronary Heart Disease Among HIV-Positive Patients-Follow-Up Through June 2000 (February 7, 2001)
In The 8th Conference on Retroviruses and Opportunistic Infections, from The Body PRO - Human Immunodeficiency Virus Infection, AIDS, and Smoking Cessation: The Time Is Now (September 2000)
In Clinical Infectious Diseases - Impact of Highly Active Antiretroviral Therapy in HIV-Positive Patients With Cardiac Involvement (May 2000)
In Journal of Infection - Cardiac Manifestations of Acquired Immunodeficiency Syndrome (March 13, 2000)
In Archives of Internal Medicine - Myocarditis and Cardiotropic Viral Infection Associated With Severe Left Ventricular Dysfunction in Late-Stage Infection With Human Immunodeficiency Virus (October 1994)
In Journal of the American College of Cardiology - HIV JournalView: Niacin Revisited (August 2004)
Analysis of a study published in Clinical Infectious Diseases on niacin as a lipid-lowering therapy.
From The Body PRO - Cardiovascular Manifestations of HIV Infection (August 2001)
In Journal of the Royal Society of Medicine
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