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Found 40 studies with search of:   tmc114

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1 Completed TMC114-C202: A Study of Safety, Efficacy, and Tolerability of TMC114 and Low Dose Ritonavir in HIV-1 Infected Patients
Condition: HIV Infections
Interventions: Drug: TMC114/rtv;   Drug: TMC114/rtv;   Drug: TMC114/rtv;   Drug: TMC114/rtv
2 Completed TMC114-C213: A Phase II Randomized, Controlled, Partially Blinded Trial to Investigate Dose-Response of TMC114/RTV in 3-Class-Experienced HIV-1 Infected Patients, Followed by an Open-Label Period on the Recommended Dose of TMC114/RTV.
Condition: HIV
Intervention: Drug: TMC114; darunavir; Prezista
3 Recruiting TMC114-C226: An Early Access Program to Evaluate the Long-Term Safety and Tolerability of TMC114 Combined With a Low Dose of Ritonavir ("TMC114/r") With Other Antiretrovirals, for HIV-1 Infected Patients Who Have Failed Multiple Antiretroviral Regimens.
Condition: HIV Infections
Intervention: Drug: TMC-114
4 Terminated TMC114-C227: A Study to Evaluate the Effectiveness and Safety of TMC114 (Darunavir) With a Low Dose of Ritonavir as Monotherapy (no Other Anti-HIV Drugs Will be Given) in Patients Who Have Never Been Treated With Antiretrovirals (Anti-HIV Drugs) Previously
Condition: HIV Infections
Intervention: Drug: TMC114 (darunavir) / ritonavir
5 Active, not recruiting A Pediatric Trial to Provide Dose Recommendation of TMC114/Rtv in HIV-1 Infected Children and Adolescents
Conditions: HIV Infections;   HIV-1
Interventions: Drug: TMC114/rtv Part I and Part II(20-50kg);   Drug: TMC114/rtv Part I and Part II (20-50kg);   Drug: TMC114/rtv Part III (Adult dose>50kg)
6 Completed TMC114-C209: A Study of Safety of TMC114 With Low Dose Ritonavir (RTV) and Other Antiretrovirals in Experienced HIV-1 Infected Patients With Limited or no Treatment Options
Condition: HIV Infections
Intervention: Drug: TMC114
7 Active, not recruiting TMC114-C214: Trial of TMC114 Administered With Low Dose Ritonavir (RTV) in HIV-1 Infected Treatment Experienced Patients
Condition: HIV Infection
Interventions: Drug: LPV/rtv;   Drug: TMC114/rtv
8 Active, not recruiting TMC114-C211: Trial of an Investigational Protease Inhibitor TMC114 With Ritonavir ("TMC114/r") in HIV-1 Infected Patients Who Have Never Been Treated With Antiretroviral Medications.
Conditions: HIV;   Anit-Retroviral Agents
Interventions: Drug: LPV/RTV;   Drug: TMC-114/RTV
9 Active, not recruiting GRACE: A Study to Compare the Effectiveness, Safety and Tolerability of PREZISTA (Darunavir)/Ritonavir by Gender and Race When Administered With Other Antiretroviral Medications in Human Immunodeficiency Virus (HIV) Positive Women and Men.
Condition: HIV
Intervention: Drug: darunavir; ritonavir
10 Recruiting Enfuvirtide/Current Protease Inhibitor Switch to PREZISTA (Darunavir)/Ritonavir + TMC125 in HIV Patients With Enfuvirtide Side Effects.
Condition: HIV
Intervention: Drug: TMC125, Darunavir; Ritonavir
11 Active, not recruiting An Open Label Trial of TMC114/RTV in HIV-1 Infected, Treatment-Experienced Subjects.
Condition: HIV Infection
Intervention: Drug: TMC114
12 Recruiting Genetic Predictors of Variability in the Drug-Drug Interaction Between Darunavir/Ritonavir and Pravastatin
Conditions: HIV Infections;   Hyperlipidemia
Intervention: Drug: Pravastatin, darunavir, ritonavir
13 Active, not recruiting TMC114-TiDP31-C229: This is a Study on the Effectiveness, Safety and Tolerability of Darunavir (DRV), Administered With Low-Dose Ritonavir (Rtv) as 800/100 mg Daily Versus 600/100 mg Twice Per Day for HIV-1 Patients Over a 48-Week Treatment Period.
Condition: HIV-1
Interventions: Drug: TMC114/rtv;   Drug: TMC-114/rtv
14 Active, not recruiting Study Comparing Efficacy and Safety of Darunavir Boosted With Ritonavir to HART With 2 NRTI and Darunavir Boosted With Ritonavir in HIV-1 Infected Patients
Condition: HIV Infections
Interventions: Drug: Darunavir;   Drug: ritonavir
15 Active, not recruiting A Study to Evaluate the Pharmacokinetic Profile (How the Body Absorbs, Distributes, Metabolizes, and Eliminates a Drug), of TMC125 Plus Tenofovir/Emtricitabine Once Daily With or Without Darunavir/r Once Daily in Antiretroviral (ARV) Nave HIV-1 Patients (Patients Have Never Received ARV Treatment).
Condition: HIV-1 Infection
Intervention: Drug: TMC125; darunavir; ritonavir
16 Not yet recruiting Changes in Triglyceride and Other Lipids (Levels of Fats Found in Blood) When Taking Darunavir Compared to Atazanavir in HIV-Infected Patients That Have Never Received Treatment.
Condition: HIV
Interventions: Drug: darunavir;emtricitabine [FTC]/tenofovir [TDF];ritonavir;   Drug: atazanavir;emtricitabine [FTC]/tenofovir [TDF];ritonavir
17 Active, not recruiting TMC114-TiDP3-C181: Study to Assess the Pharmacokinetics of Darunavir (DRV) With Different Doses of Ritonavir in Healthy Volunteers.
Conditions: AIDS;   HIV
Intervention: Drug: Darunavir
18 Completed TMC114-TiDP29-C169: Bioavailability and Pharmacokinetics Trial Compairing Darunavir Pediatric Suspension Formulation to Current Darunavir Tablet
Condition: Pharmacokinetics
Intervention: Drug: Darunavir
19 Active, not recruiting Treatment Simplification by Darunavir/Ritonavir 800/100 mg Once a Day Versus a Triple Combination Therapy With Darunavir/Ritonavir
Conditions: HIV Infections;   Human Immunodeficiency Virus;   Acquired Immunodeficiency Syndrome Virus;   AIDS Virus
Intervention: Drug: darunavir
20 Active, not recruiting Clinical Trial to Assess the Efficacy of Darunavir/Ritonavir (DRV/r), Etravirine (ETV) and Raltegravir (MK-0518) in HIV Patients With Resistant Viruses
Condition: HIV Infections
Interventions: Drug: raltegravir potassium;   Drug: darunavir/ritonavir;   Drug: etravirine;   Drug: Optimized background regimen
21 Active, not recruiting Efficacy Study of Substitution of Darunavir/Ritonavir (DRV/r) for Dual-Boosted Protease Inhibitors
Condition: HIV Infections
Interventions: Drug: dual boosted protease inhibitor;   Drug: darunavir
22 Recruiting Abacavir Pharmacokinetic Study
Condition: HIV
Interventions: Drug: Abacavir;   Drug: Darunavir/ritonavir;   Drug: Raltegravir
23 Not yet recruiting A Double-Blind, Placebo-Controlled, Crossover, Dose Escalating Study To Evaluate The Safety, Tolerability And Pharmacokinetics Of Single Oral Doses Of PF-03716539 In Healthy Adult Subjects
Condition: Healthy Volunteers
Interventions: Drug: PF-03716539;   Drug: PF-03716539;   Other: Placebo;   Drug: PF-03716539;   Drug: PF-03716539;   Drug: PF-03716539;   Other: Placebo;   Drug: PF-03716539;   Drug: Midazolam;   Drug: Midazolam + PF-03716539 (100 mg);   Drug: Midazolam + PF-03716539 (50 mg);   Drug: Darunavir;   Drug: Darunavir + PF-03716539;   Drug: Maraviroc;   Drug: Maraviroc + PF-03716539
24 Active, not recruiting Evaluate the Efficacy and Security of Darunavir/Ritonavir 900/100 mg Once a Day as an Antiretroviral Treatment Simplification Strategy
Condition: HIV Infections
Intervention: Drug: Darunavir 900mg + ritonavir 100 mg once a day
25 Not yet recruiting Raltegravir And Darunavir Antiretroviral in Antiretroviral Naive Patients
Condition: HIV Infections
Interventions: Drug: Raltegravir;   Drug: Darunavir;   Drug: Ritonavir;   Drug: Tenofovir/Emtricitabine
26 Active, not recruiting Double Protease Inhibitor to Darunavir Switch Study
Condition: HIV Infections
Intervention: Drug: Darunavir ritonavir
27 Recruiting Lopinavir/r or Fosamprenavir/r Switch to Atazanavir/r or Darunavir/r
Condition: HIV Infections
Interventions: Drug: atazanavir/ritonavir;   Drug: darunavir/ritonavir
28 Completed VX-950-TiDP24-C124: A Phase I Trial to Investigate the Potential Pharmacokinetic Interactions Between Telaprevir and Darunavir/Ritonavir and Between Telaprevir and Fosamprenavir/Ritonavir at Steady-State.
Conditions: HIV;   Telaprevir;   Hepatitis C
Intervention: Drug: Telaprevir; Darunavir; Ritonavir; Fosamprenavir
29 Terminated Comparison of TPV/r to DRV/r in Triple Class Experienced Patient With Resistance to > 1 PI
Condition: HIV Infections
Interventions: Drug: Tipranavir;   Drug: Darunavir;   Drug: Ritonavir
30 Recruiting NNRTI/PI Toxicity Switch to Darunivir Study.
Condition: HIV
Interventions: Drug: darunavir;   Drug: ritonavir
31 Active, not recruiting TMC125-C206: A Phase III Study to Investigate the Efficacy, Tolerability and Safety of TMC125 as Part of an Antiretroviral Regimen, Including TMC114/Ritonavir and an Investigator-Selected Optimized Background, in HIV-1 Infected Patients With Limited to no Treatment Options.
Condition: HIV
Interventions: Drug: TMC125;   Drug: Placebo
32 Active, not recruiting TMC125-C216: A Phase III Study to Investigate the Efficacy, Tolerability and Safety of TMC125 as Part of an Antiretroviral Regimen, Including TMC114/Ritonavir and an Investigator-Selected Optimized Background, in HIV-1 Infected Patients With Limited to no Treatment Options.
Condition: HIV
Interventions: Drug: TMC125;   Drug: Placebo
33 Recruiting GSK1349572 Drug Interaction Study With Protease Inhibitors
Condition: Healthy Subjects
Interventions: Drug: GSK1349572;   Drug: GSK1349572
34 Recruiting An Open-Label Trial With TMC125 in Patients Who Have Virologically Failed in a DUET Trial (TMC125-C206 or TMC125-C216).
Condition: HIV-1
Intervention: Drug: TMC125
35 Recruiting Study to Determine the Pharmacokinetic Behavior of Antiretroviral Drugs in Patients Infected by HIV
Condition: HIV Infections
Interventions: Drug: Nevirapine;   Drug: Efavirenz;   Drug: Indinavir/ritonavir;   Drug: Nelfinavir;   Drug: Saquinavir/ritonavir;   Drug: Lopinavir/ritonavir;   Drug: Atazanavir;   Drug: Atazanavir/ritonavir;   Drug: Fos-amprenavir/ritonavir;   Drug: Tipranavir/ ritonavir;   Drug: Darunavir/ritonavir
36 Recruiting Characterization of Acute and Recent HIV-1 Infections in Zurich: a Long-Term Observational Study
Condition: HIV Infections
Interventions: Drug: lopinavir;   Drug: atazanavir;   Drug: efavirenz;   Drug: fosamprenavir;   Drug: darunavir;   Drug: tipranavir;   Drug: ritonavir;   Drug: nevirapine;   Drug: zidovudine;   Drug: lamivudine;   Drug: tenofovir;   Drug: emtricitabine;   Drug: abacavir
37 Recruiting Blood Levels of Anti-HIV Drugs Used in Combination Regimens in HIV Infected Children
Condition: HIV Infections
Interventions: Drug: Atazanavir;   Drug: Darunavir;   Drug: Efavirenz;   Drug: Nevirapine;   Drug: Ritonavir;   Drug: Tenofovir disoproxil fumarate;   Procedure: Pharmacokinetic Study
38 Not yet recruiting Maraviroc Versus Etravirine In Combination With Antiretroviral Therapy In Drug Experienced HIV And Hepatitis Co-Infected Patients
Conditions: Hepatitis B;   Human Immunodeficiency Virus;   Hepatitis C, Chronic
Interventions: Drug: maraviroc;   Drug: etravirine
39 Recruiting Optimizing Treatment for Treatment-Experienced, HIV Infected People
Condition: HIV Infections
Interventions: Drug: Enfuvirtide;   Drug: Raltegravir;   Drug: Darunavir;   Drug: Tipranavir;   Drug: Etravirine;   Drug: Maraviroc
40 Recruiting Clinical Trial of CNS-Targeted HAART (CIT2)
Condition: HIV Infections
Intervention: Drug: FDA Approved Antiretroviral Therapy (see list below)

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