"The catastrophic collision of tuberculosis and human immunodeficiency virus (HIV) has yielded an extraordinary burden of suffering and death at both the individual and population levels," write the authors of a Journal of Infectious Diseases Editorial Commentary that examines the challenges associated with trying to prevent and manage the two diseases. "Interventions to control tuberculosis and HIV therefore need to take into account the unique and deadly synergy between these 2 infections," they continue. The piece outlines a growing body of evidence documenting TB recurrence in patients with HIV following the successful completion of treatment (Chaisson/Churchyard, 2/1).

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