February 4, 2010
Antiretroviral therapy based on efavirenz (EFV) is more effective than lopinavir/ritonavir (LPV/r)-based therapy among treatment-naïve patients with advanced disease, a new study found.
Among the EFV and LPV/r groups, 85 percent of whom were men, median baseline CD4+ counts were 64 and 52/mm3 respectively (P=not significant). By the 48th week, 70 percent of EFV and 53 percent of LPV/r patients had viral loads of under 50 copies/mL (estimated difference 17 percent [95 percent confidence interval 3.5 to 31], P=0.013). The proportion for under 400 copies/mL was 73 percent with EFV and 65 percent with LPV/r (P=0.25). Virologic failure occurred in seven EFV patients and 17 LPV/r patients. Increases in mean CD4+ cell counts were 234/mm3 for EFV and 239/mm3 for LPV/r. Mean change in total cholesterol and triglycerides was 50mg/dL and 48mg/dL in EFV and 63 mg/dL and 116mg/dL in LPV/r (P=0.24 and P less than 0.01).
"In these very advanced HIV-infected ARV-naïve subjects, EFV-based highly active antiretroviral therapy had superior virologic efficacy than LPV/r-based highly active antiretroviral therapy, with a more favorable lipid profile," concluded the study authors.
01.2010; doi: 10.1097/QAI.obo13e3181cae4a1; Juan Sierra-Madero, M.D. and others