"Despite the enormous progress made in scaling up antiretroviral therapy (ART) in sub-Saharan Africa, many challenges remain, not least of which are the identification and management of patients who have failed first-line therapy," write the authors of a Lancet Infectious Diseases Personal View piece that examines the current challenges associated with diagnosing and managing ART failure in resource-limited settings in the region. The development of a point-of-care HIV viral-load test "combined with simple and inexpensive second-line therapy, such as boosted protease-inhibitor monotherapy, could revolutionise the management of ART failure in resource-limited settings," according to the authors (Harries et al., 1/10).
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