October 26, 2009
In population studies, higher coffee consumption has been inversely associated with chronic liver disease incidence. Now a new study has found that a few cups of coffee a day seem to help prevent the progression of hepatitis C-related liver disease.
The study involved 766 participants in the Hepatitis C Antiviral Long-Term Treatment against Cirrhosis trial who had HCV-related bridging fibrosis or cirrhosis on liver biopsy and who failed to respond to peginterferon plus ribavirin. Baseline coffee and tea intake were assessed among patients, who were seen every three months and given liver biopsies at 1.5 years and 3.5 years.
"We observed an inverse association between coffee intake and liver disease progression," wrote Neal D. Freedman of the National Cancer Institute and colleagues. HCV liver disease-related clinical outcomes declined with increased coffee consumption: 11.1/100 person-years for no coffee, 12.1 for less than one cup per day, 8.2 for one to fewer than three cups per day, and 6.3 for three or more cups per day (P-trend=0.0011). Compared with not drinking coffee, relative risks at 95 percent confidence intervals were 1.1 (0.76-1.61) for less than one cup a day; 0.70 (0.48-1.02) for one to fewer than three cups a day; and 0.47 (0.27-0.85) for three or more cups per day.
Agence France Presse
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