June 2, 2000
The International AIDS Vaccine Initiative (IAVI) will fund testing of a new kind of preventive vaccine, which has been developed at the Institute for Human Virology (IHV), started in 1996 by Robert Gallo, M.D., at the University of Maryland. IAVI funds promising AIDS vaccines under intellectual-property agreements which will help make successful ones available at affordable prices to developing countries.
The new vaccine will be taken orally, and could possibly cost less than $1 per dose to produce.
Several aspects of this technology are particularly important:
This vaccine is well along in its development, but clinical trials are still more than a year away. The first trials will take place in Baltimore and in Uganda, where the Ministry of Health is an active participant in this program. One trial will compare this vaccine head to head against an injected formulation which uses the same active ingredients but a very different delivery system -- a vaccine also being funded by IAVI.
"The driving force for this decade-long effort [to create the new vaccine] has been the development of a simple delivery system for an HIV vaccine that can be administered without needles and that can be afforded by developing nations. Salmonella-DNA has these attributes built in from the start. We are extremely excited now to be able to evaluate this strategy in human volunteers," said Dr. George Lewis, Director of the IHV Division of Vaccine Research.
ISSN # 1052-4207
Copyright 2000 by John S. James. Permission granted for noncommercial reproduction, provided that our address and phone number are included if more than short quotations are used.
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