June 29, 2004
One factor affecting the ability of these lesions to transform into a more dangerous state is the certain subtype of HPV a person is infected with. Subtypes such as HPV-16, HPV-18 and HPV-31 are linked to the development of pre-cancerous growths as well as cancer of the cervix, anus and penis. Another target that HPV attacks in women is the vulva. Researchers in the United States have conducted a study in two groups -- 1,562 HIV positive women and 469 HIV negative women -- to find out about risk factors for developing the following:
The research team monitored HIV women for up to eight years. Key findings were as follows:
Further details about the impact of HAART on genital warts and vulvar cancer appear later in this story.
All participants underwent detailed medical interviews twice a year, had vulvar examinations and, if lesions were present, then gynecologists had a closer look at the lesions with vulvar colposcopy. Biopsies were taken from lesions but not genital warts. Blood samples were collected and analysed. On average, women in this study were between 30 and 40 years old, 50% were black, 80% had children, and at least half the women were smokers. This study was part of the Womens Interagency HIV Study (WIHS).
As with genital warts, HIV positive women were three times more likely than HIV negative women to have abnormal cells on their vulva. The good news was that generally these cells in both groups were only mildly abnormal. Other findings included the following:
There were no cases of vulvar cancer among HIV negative women in this study. Despite twice-yearly tests and examinations, three cases of vulvar cancer occurred among 1,562 HIV positive women over eight years. The good news is that these cancers were detected at an early stage in their development, perhaps because of frequent medical check-ups.
In this study HIV positive women who had abnormal Pap smear results were highly likely to also have abnormal growths on their vulva. Yet, colposcopic examination of the vulva was not a routine part of this study and most abnormal growths on the vulva were found by simply having a gynecologist closely examine them with the naked eye. Therefore, based on the results of their study, the research team does not encourage the regular use of vulvar colposcopy for HIV positive women. They do emphasize that "careful genital inspection is mandatory" for all women who have abnormal Pap smears. Also, women with visible growths on their vulva should have biopsies performed to assess the nature of these growths. This study underscores the need for HIV positive women to receive regular gynecologic exams, including Pap smears.