Another report from France also noted the onset of acute CMV infections among 8 patients with low CD4 counts (mean = 37) who were started on combination therapy including protease inhibitors. Acute CMV infection (retinitis, submaxillitis, pseudotumoral colitis, pneumonitis, CMV viremia) occurred despite clinical improvement of the patients and an increase by more than 5 fold in mean CD4 counts. The average time from the first administration of protease inhibitors and the onset of the CMV event was 37 days. In contrast most other studies presented at the conference noted declines in the incidence of other major opportunistic infections, and even resolution of some without specific antiinfective and antitumor therapy, including chronic cryptosporidiosis, progressive multifocal leukoen- cephalopathy and Kaposi's sarcoma, wasting syndrome and Parvo virus infections. One study however reported that HAART could unmask subclinical Mycobacterium avium complex infections localized to lymph nodes or skin by way of enhanced immune responses.
The content on this page is free of advertiser influence and was produced by our editorial team. See our content and advertising policies.