October 3, 2002
Previous studies have shown strong associations between acquisition of HCV infection and sharing of drug paraphernalia -- both "direct" sharing of needles and syringes and "indirect" sharing of cookers, cotton filters, and backloading -- the practice of preparing drugs from the barrel of one syringe and transferring them to another syringe. HCV transmission is also closely related to duration of injection drug use: among persons newly initiated into injection drug use in Baltimore, 65 percent had acquired HCV within 1 year of initiating injection behavior.
The authors of the current study sought to evaluate changes in high risk behaviors associated with HCV transmission through both "direct" and "indirect" sharing of injection paraphernalia after disclosure of a positive HCV antibody test. The study evaluated 60 IDUs through semi-annual interviews, HIV and HCV antibody testing and pre-test and post-test counseling. The authors also assessed changes in alcohol consumption among those with a positive HCV test result.
The study consisted of a post hoc analysis of data from the Risk Evaluation and Community Health (REACH) II Study -- a study of HIV risk among young, recently initiated IDUs in Baltimore. Participants included 226 IDUs enrolled in the REACH II Study between July 1997 and May 1999. Eligibility for the study included being 15-30 years old; having initiated injection drug use no more than 5 years prior to the study; and having injected illicit drugs at least once in the past 6 months. Informed consent was received from each participant.
Among the participants of the REACH II Study, the majority were African-American (61 percent) and female (64 percent). The mean age at enrollment was 26 years; age of first use of injection drugs was 23 years; and the median length of time using injection drugs was 2.1 years. The baseline prevalence of HCV and HIV infection were 60.5 percent and 10.6 percent, respectively; 7.7 percent of participants were coinfected with HCV and HIV. Baseline demographics were similar for both HCV-positive and non-HCV groups with respect to sex, age, homelessness, and alcohol dependence. At baseline, 43 percent of participants were alcohol dependent.
In the study of young IDUs who were seropositive for HCV and were informed of their serostatus, fewer than one-fifth of the study subjects had reductions in direct sharing of needles. Almost three-quarters of participants reported that they continued to practice backloading drugs. The pattern was especially apparent among HCV-infected subjects aware of their serostatus, of whom over 75 percent continued to backload. Over one-third continued to share needles.
According to the authors, the "...findings suggest that young IDUs may not be aware of the risk of HCV infection and highlight the urgent need for post-HCV test guidelines and behavioral interventions to reduce ongoing high-risk behavior that perpetuates the risk of HCV transmission."
Clinical Infectious Diseases
10.01.02; Vol. 35: P. 783-788; Danielle C. Ompad; Crystal M. Fuller; David Vlahov; David Thomas; Steffanie A. Strathdee
The content on this page is free of advertiser influence and was produced by our editorial team. See our content and advertising policies.
|What Would an HIV Cure Mean for You?|
|Condomless Anal Sex Rising in U.S. MSM With or Without HIV Infection|
|If We Act to Remove Structural, Behavioral and Social Barriers, We Can End the HIV Epidemic With the Medicines We Already Have|
|This Week in HIV Research: Immune System Differences Could Produce bNAbs; New HIV Infections Are No Longer Falling; and Zoledronic Acid May Prevent Bone Loss|
|What's the Next Game-Changer in HIV Treatment?|