October 9, 2002
The evaluated patients, whose average age was 35.7 +/- 8.7 years, were in various stages of liver disease, HCV, and HIV. Upon histological evaluation a majority of them demonstrated moderate hepatitis. However, those with higher immune competence showed more severe hepatitis. "Statistical analysis showed a significant association of CD4 count <50 with minimal hepatitis and of CD>200 with mild and moderate hepatitis (p=0.33)," reported J. Delladetsima of the University of Athens Medical School in Greece.
Stage C is a classification for greater symptomatology in HIV infection. Most of the patients with this stage of disease demonstrated only minimal hepatitis, whereas those at stage A, a classification for lesser HIV symptomatology, had mild-to-moderate hepatitis, according to researchers. The full report, "Significance of Immune Status, Genotype and Viral Load in the Severity of Chronic Hepatitis C in HIV Infected Haemophilia Patients," was published in Haemophilia (September 2002;8(5):668-673).
"No relationship was found between hepatitis severity, HIV or HCV RNA levels, patient's age and duration of HIV or HCV infection," researchers noted. Immunocompetence, rather than immunodeficiency, may be a hallmark for more aggressive hepatitis in hemophilia patients coinfected with HIV and HCV, Delladetsima and colleagues suggested.
09.16.02; Sonia Nichols