July 9, 2002
Blanco and colleagues from Barcelona, Spain reported their results of a small study looking at the use of either 1,200 amprenavir/200 ritonavir QD (n = 10) or 600 amprenavir/200 ritonavir BID (n = 11) in patients failing a protease inhibitor-based regimen. The median viral load at the time of switch to the amprenavir/ritonavir regimen was 4.1 log while the CD4 count was lower in the BID group (184 versus 326). The study was very small and results for only 13 of the patients were available at 24 weeks of treatment. None of five BID patients and 4/8 of the QD patients had RNA levels less than 200 copies/ml at 24 weeks. Virtual phenotype and number of protease inhibitor mutations seemed to predict virologic activity. Though the authors concluded that the QD regimen was superior, I would take issue with that considering the limited number of patients, the short term of observation and the lower CD4 count for the BID group at baseline.
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