October 27, 2001
This is a good study of an AZT-less regimen. The combination of ABC and 3TC for the nucleosides is combined with amprenavir for the protease inhibitor. This could also be a regimen that is very unlikely to cause lipdystrophy or mitochondrial toxicity. Only one patient had the classic abacavir hypersensitivity reaction. Patients were naive to antiretrovirals and there was a good drop in HIV viral load and a rise of 170 in CD4 cells over 48 weeks. Basically, this regimen is as good as any NRTI/PI regimen with 69% of patients having <400 copies at 48 weeks. According to the authors, APV/RTV trials are underway to make this an easier-to-take regimen.
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