October 27, 2001
This is a study from the CHORUS database with which I was involved. It looked at patients in the database who were switched from nelfinavir (NLF) to amprenavir or amprenavir/ritonavir (APV/RTV) regimens. The real-life question that this study answers is, "is there cross-resistance between nelfinavir and amprenavir?"
The answer gleaned from this data is that there is apparently no cross-resistance between nelfinavir and amprenavir. This clinical data supports the genotypic and phenotypic data that amprenavir salvage should work in nelfinavir-experienced patients. Only 17% of patients taking amprenavir for a median of 385 days discontinued due to side effects. This suggests that amprenavir is well tolerated. Other randomized trials addressing this question are in progress, however this is good news, suggesting that there is a good option after nelfinavir failure.
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