February 7, 2001
In the CNAF3007 study abacavir (n=96) versus nelfinavir (n=92) in combination with AZT/3TC was compared. A poster presented by Matheron and colleagues examined metabolic and body fat parameters at 48 weeks. The 48-week virologic results found that 65% of the abacavir and 61% of the nelfinavir group had plasma RNA <50 copies/mL (no significant difference). The cholesterol level increased significantly more in the nelfinavir arm while the greater triglyceride increase in the nelfinavir was not statistically significant. Both groups had a small increase in glucose levels. Six patients in the abacavir arm and eleven patients in the nelfinavir arm were reported to develop fat redistribution by 48 weeks (not statistically different). The excess cases in the nelfinavir group consisted of lipoatrophy and venous abnormalities in the legs.
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